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A reduction in estrogen in postmenopausal women increases the activity of osteoclasts, leading to an increase in bone resorption and progressive bone loss. During this process, two kinds of cells, osteoclasts and osteoblasts, which are rigorously coordinated by various cytokines and hormones, are balanced. The primary component is the superoxide radical, which is one of the highly reactive species that osteoblasts must replenish when osteoclasts create tiny holes. This study contains a brief outline of the awareness of the mechanism for the reversal of bone loss, gender-, physiological-, and age-related skeletal osteopenia resulting in osteoporosis, and the function of antioxidants in bone repair and in bone loss.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>This review is the report of a systematic review on the pervasiveness of osteoporosis worldwide.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02601060261491806","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:49:58Z","timestamp":1790682598000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A comprehensive review on osteoporosis in women and beneficial effects of antioxidants on osteoporosis: A systematic review"],"prefix":"10.1177","author":[{"given":"Ritu","family":"Panchal","sequence":"first","affiliation":[{"name":"Banasthali Vidyapith, Banasthali"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya","family":"Kumari","sequence":"additional","affiliation":[{"name":"Banasthali Vidyapith, Banasthali"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7901-0006","authenticated-orcid":false,"given":"Priya","family":"Chaudhary","sequence":"additional","affiliation":[{"name":"Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education"},{"name":"Department of Pharmacology, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0500-4636","authenticated-orcid":false,"given":"Pracheta","family":"Janmeda","sequence":"additional","affiliation":[{"name":"Banasthali Vidyapith, Banasthali"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Prakash","sequence":"additional","affiliation":[{"name":"Banasthali Vidyapith, Banasthali"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20143576"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.15419\/bmrat.v10i7.819"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31825f0466"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/13697130310001651454"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.4183\/aeb.2022.355"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12252"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-009-8416-8"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.20960\/nh.1800"},{"issue":"1","key":"e_1_3_3_10_1","first-page":"4840531","article-title":"The effectiveness of physical exercise on bone density in osteoporotic patients","volume":"2018","author":"Benedetti MG","year":"2018","unstructured":"Benedetti MG, Furlini G, Zati A, et al. 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