{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:03:41Z","timestamp":1790949821425,"version":"4.1.0"},"reference-count":54,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Nutr Health"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hypertension, erectile dysfunction, and dyslipidemia are interrelated conditions strongly driven by poor dietary habits dominated by refined carbohydrate snacks and high-fat fast foods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study investigated the potential of functional crackers formulated from tiger nut, unripe plantain, and sorghum flours to ameliorate N-nitro-l-arginine methyl ester and high-fat diet-induced hypertension and erectile dysfunction in Wistar rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Composite crackers were prepared in different proportions and evaluated for effects on blood pressure, sexual behavior, lipid profile, nitric oxide (NO) bioavailability, and key enzymes linked to vasodilation including angiotensin-1 converting enzyme (ACE), phosphodiesterase-5 (PDE-5), and arginase in the kidney, penile, and heart tissues.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>Functional crackers, particularly the 50% tiger nut + 25% unripe plantain + 25% sorghum formulation, significantly lowered systolic and diastolic blood pressure, improved sexual performance, and corrected dyslipidemia. The functional crackers enhanced NO production and modulated ACE, PDE-5, and arginase. The functional crackers were also richer in polyphenols and potassium but lower in sodium than conventional crackers. These findings highlight composite functional crackers as a promising, food-based strategy for managing hypertension and erectile dysfunction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02601060261492018","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:50:32Z","timestamp":1790682632000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Functional crackers from tiger nut, unripe plantain, and sorghum flours improve vascular and sexual health in hypertensive rats"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9767-1844","authenticated-orcid":false,"given":"Ayokunle","family":"Ademosun","sequence":"first","affiliation":[{"name":"Federal University of Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adekemi","family":"Olusola-Ajamu","sequence":"additional","affiliation":[{"name":"Federal University of Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganiyu","family":"Oboh","sequence":"additional","affiliation":[{"name":"Federal University of Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeniyi","family":"Adebayo","sequence":"additional","affiliation":[{"name":"Osun State University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/23312009.2017.1383707"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foohum.2024.100428"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13596-017-0292-8"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jafr.2023.100693"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mnh.0000441047.13912.56"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-6175.2006.06026.x"},{"issue":"3","key":"e_1_3_3_8_1","first-page":"178","article-title":"Estimation of total flavonoid content in propolis by two complementary colorimetric methods","volume":"10","author":"Chang C","year":"2002","unstructured":"Chang C, Yang M, Wen H, et al. 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