{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:29:36Z","timestamp":1790270976682,"version":"4.1.0"},"reference-count":48,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Altern Lab Anim"],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:p>\n                    The Frog Embryo Teratogenesis Assay-Xenopus (FETAX) is a powerful and flexible bioassay that makes use of the embryos of the anuran amphibian Xenopus laevis. The FETAX can detect xenobiotics that affect embryonic development, when mortality, teratogenicity and growth inhibition are used as endpoints. The FETAX was used to compare the embryotoxic and teratogenic potentials of two chemical species of mercury: inorganic mercury(II) chloride (HgCl\n                    <jats:sub>2<\/jats:sub>\n                    ) and organic methylmercury chloride (MeHgCl). MeHgCl, with an estimated median lethal concentration [LC50] of 0.313\u03bcM and a median teratogenic concentration [TC50] of 0.236\u03bcM, showed a higher toxicity than HgCl\n                    <jats:sub>2<\/jats:sub>\n                    , with estimated LC50 and TC50 values of 0.601\u03bcM and 0.513\u03bcM, respectively. On the basis of these results, HgCl\n                    <jats:sub>2<\/jats:sub>\n                    and MeHgCl can be classified as \u201cslightly teratogenic compounds\u201d, as the ratio of LC50\/TC50 is less than 1.5. There was a significant deviation from the commonly described monotonic behaviour of the concentration\u2013response curves, suggesting a hormetic effect of both species of mercury. Uptake experiments, followed by neutron activation analysis, showed a higher incorporation of mercury in embryos exposed to MeHgCl compared with those exposed to HgCl\n                    <jats:sub>2<\/jats:sub>\n                    . Interestingly, Hg-exposed embryos showed a higher content of selenium and zinc than did control embryos.\n                  <\/jats:p>","DOI":"10.1177\/026119290203000104","type":"journal-article","created":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T00:28:46Z","timestamp":1554856126000},"page":"23-32","source":"Crossref","is-referenced-by-count":24,"title":["A Comparative Study of the Toxicity of Mercury Dichloride and Methylmercury, Assayed by the Frog Embryo Teratogenesis\n                    <i>Assay-Xenopus<\/i>\n                    (FETAX)"],"prefix":"10.1177","volume":"30","author":[{"given":"Mariangela","family":"Prati","sequence":"first","affiliation":[{"name":"Department of Structural and Functional Biology, Universit\u00e0 dell'Insubria, 3 Via Dunant, 21100 Varese, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalba","family":"Gornati","sequence":"additional","affiliation":[{"name":"Department of Structural and Functional Biology, 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