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The award-winning work centred on the development of \u2018The Adverse Outcome Pathway for Skin Sensitisation Initiated by Covalent Binding to Proteins\u2019. This Adverse Outcome Pathway (AOP) has provided the mechanistic basis for the integration of skin sensitisation-related information. Recent developments in integrated approaches to testing and assessment, based on the AOP, are summarised. The impact of the AOP on regulatory policy and on the Three Rs are discussed. An overview of the next generation of the skin sensitisation AOP module in the OECD QSAR Toolbox, based on more-recent work at the Laboratory of Mathematical Chemistry, is also presented.<\/jats:p>","DOI":"10.1177\/026119291604400515","type":"journal-article","created":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T04:44:35Z","timestamp":1554785075000},"page":"453-460","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["The Adverse Outcome Pathway for Skin Sensitisation: Moving Closer to Replacing Animal Testing"],"prefix":"10.1177","volume":"44","author":[{"given":"Terry W.","family":"Schultz","sequence":"first","affiliation":[{"name":"The University of Tennessee, College of Veterinary Medicine, Knoxville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gergana","family":"Dimitrova","sequence":"additional","affiliation":[{"name":"Laboratory of Mathematical Chemistry (LMC), As. Zlatarov University, Bourgas, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabcho","family":"Dimitrov","sequence":"additional","affiliation":[{"name":"Laboratory of Mathematical Chemistry (LMC), As. Zlatarov University, Bourgas, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ovanes G.","family":"Mekenyan","sequence":"additional","affiliation":[{"name":"Laboratory of Mathematical Chemistry (LMC), As. Zlatarov University, Bourgas, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,10,1]]},"reference":[{"key":"bibr1-026119291604400515","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2014.04.018"},{"key":"bibr2-026119291604400515","doi-asserted-by":"crossref","unstructured":"OECD (2011). Series on Testing and Assessment No. 138: Report of the Workshop on Using Mechanistic Information in Forming Chemical Categories, 8\u201310 December 2010, Crystal City, VA, USA, ENV\/JM\/MONO(2011)8, 18.05.2011, 176 pp Paris, France: Organisation for Economic Co-operation and Development.","DOI":"10.1787\/1648b49f-en"},{"key":"bibr3-026119291604400515","doi-asserted-by":"crossref","unstructured":"OECD (2011). Series on Testing and Assessment No. 139: Report of the Expert Consultation on Scientific and Regulatory Evaluation of Organic Chemistry-based Structural Alerts for the Identification of Protein-binding Chemicals, ENV\/JM\/MONO (2011)9, 05.04.2011, 100 pp. Paris, France: Organisation for Economic Co-operation and Development.","DOI":"10.1787\/1648b49f-en"},{"key":"bibr4-026119291604400515","unstructured":"OECD (2012). OECD Series on Testing and Assessment No. 168: The Adverse Outcome Pathway for Skin Sensitisation Initiated by Covalent Binding to Proteins. 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