{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:05:29Z","timestamp":1787018729527,"version":"build-2736575974"},"reference-count":35,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T00:00:00Z","timestamp":1676419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Centre for Plant Materials and Herbal Products Research, University of Sri Jayewardenepura","award":["001\/2018"],"award-info":[{"award-number":["001\/2018"]}]},{"DOI":"10.13039\/501100008816","name":"University of Sri Jayewardenepura","doi-asserted-by":"publisher","award":["ASP\/RE\/MED\/2015\/42"],"award-info":[{"award-number":["ASP\/RE\/MED\/2015\/42"]}],"id":[{"id":"10.13039\/501100008816","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Altern Lab Anim"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:p>\n                    Dengue is an arboviral (insect-transmitted) infection of global concern. Currently, there are still no specific dengue antiviral agents to treat the disease. Plant extracts have been used in traditional medicine for treating various viral infections \u2014 thus, in the present study, aqueous extracts of dried flowers of\n                    <jats:italic toggle=\"yes\">Aegle marmelos<\/jats:italic>\n                    (AM), whole plant of\n                    <jats:italic toggle=\"yes\">Munronia pinnata<\/jats:italic>\n                    (MP) and leaves of\n                    <jats:italic toggle=\"yes\">Psidium guajava<\/jats:italic>\n                    (PG) were investigated for their potential capacity to inhibit dengue virus infection of Vero cells. The maximum non-toxic dose (MNTD) and the 50% cytotoxic concentration (CC\n                    <jats:sub>50<\/jats:sub>\n                    ) were determined by using the MTT assay. A plaque reduction antiviral assay was carried out with dengue virus types 1 (DV1), 2 (DV2), 3 (DV3) and 4 (DV4), in order to calculate the half-maximum inhibitory concentration (IC\n                    <jats:sub>50<\/jats:sub>\n                    ). AM extract inhibited all four virus serotypes tested; MP extract inhibited DV1, DV2 and DV4, but not DV3; PG extract inhibited DV1, DV2 and DV4, but not DV3. Thus, the results suggest that AM is a promising candidate for the pan-serotype inhibition of dengue viral activity.\n                  <\/jats:p>","DOI":"10.1177\/02611929231158243","type":"journal-article","created":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T00:40:51Z","timestamp":1676508051000},"page":"136-143","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["<i>In Vitro<\/i>\n                    Dengue Virus Inhibition by Aqueous Extracts of\n                    <i>Aegle marmelos<\/i>\n                    ,\n                    <i>Munronia pinnata<\/i>\n                    and\n                    <i>Psidium guajava<\/i>"],"prefix":"10.1177","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8604-3973","authenticated-orcid":false,"given":"Kalani Gayathri","family":"Jayasekara","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory Science"},{"name":"Faculty of Allied Health Sciences"},{"name":"University of Ruhuna"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preethi","family":"Soysa","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology"},{"name":"Faculty of Medicine"},{"name":"University of Colombo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thusharie Sugandhika","family":"Suresh","sequence":"additional","affiliation":[{"name":"Department of Biochemistry"},{"name":"Faculty of Medical Sciences"},{"name":"University of Sri Jayewardenepura"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charitha Lakshini","family":"Goonasekara","sequence":"additional","affiliation":[{"name":"Department of Pre-Clinical Sciences"},{"name":"Faculty of Medicine"},{"name":"General Sir John Kotelawala Defence University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamani Mangalika","family":"Gunasekera","sequence":"additional","affiliation":[{"name":"Department of Microbiology"},{"name":"Faculty of Medical Sciences"},{"name":"University of Sri Jayewardenepura"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,2,15]]},"reference":[{"key":"e_1_3_4_2_2","volume-title":"Dengue and severe dengue","author":"World Health Organisation","year":"2017","unstructured":"World Health Organisation. 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