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As well as providing a background overview of oral tobacco and nicotine products, this report focuses on the methods used to generate extracts from these products for\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    testing, the recommended best testing practices, and suggested areas for future research. This publication was developed by a working group of workshop members, in conjunction with the ninth IIVS\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    workshop entitled \u2018\n                    <jats:italic toggle=\"yes\">In Vitro Models for Testing Oral Tobacco and Nicotine Products and Continued Discussion of In Vitro Models of Toxicity and Disease<\/jats:italic>\n                    \u2019, which was held in January 2024.\n                  <\/jats:p>","DOI":"10.1177\/02611929261475613","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T08:08:34Z","timestamp":1786694914000},"page":"269-281","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Key challenges for\n                    <i>in vitro<\/i>\n                    testing of oral tobacco and nicotine products for regulatory applications: Recommendations for using\n 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