{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T05:05:38Z","timestamp":1779253538171,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Community Dental Health"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:p>\n                    <jats:bold>Objective:<\/jats:bold>\n                    This study aims to investigate the causal inference underlying this association through the application of Mendelian randomization (MR) analysis.\n                    <jats:bold>Basic research design:<\/jats:bold>\n                    A Two-Sample Mendelian Randomization Study.\n                    <jats:bold>Clinical setting:<\/jats:bold>\n                    NA.\n                    <jats:bold>Participants:<\/jats:bold>\n                    This study uses summary data from genome-wide association studies (GWAS) of seven antibodies targeting\n                    <jats:italic toggle=\"yes\">Helicobacter pylori<\/jats:italic>\n                    (\n                    <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                    ) and periodontal diseases, employing a two-sample MR design. It analyzed 97,830 cases and 272,252 controls for gingivitis, 4784 cases for chronic periodontitis, and 367 cases for acute periodontitis.\n                    <jats:bold>Interventions:<\/jats:bold>\n                    NA.\n                    <jats:bold>Main outcome measures:<\/jats:bold>\n                    This study aimed to overcome the limitations of observational studies and provide insights into whether\n                    <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                    plays a causal role in the development of periodontal disease (PD).\n                    <jats:bold>Results:<\/jats:bold>\n                    The genetic prediction results indicate a statistically significant association between\n                    <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                    UREA antibody levels and the risk of acute periodontitis (OR = 0.7, 95% CI: 0.50\u20130.98,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = 0.035). In the Weighted Median method, comparable results were obtained (OR = 0.61, 95% CI: 0.39 - 0.95,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = 0.028). However, we did not identify a causal association between genetically predicted levels of other\n                    <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                    antibodies and periodontal disease. For sensitivity analysis, heterogeneity was detected in studies of CagA antibody and acute periodontitis through Cochran\u2019s Q tests, and one outlier was identified using MR-PRESSO. Upon exclusion of outliers, the results remained robust and were not influenced by other factors.\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    The study results revealed a causal relationship between\n                    <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                    UREA antibody levels and acute periodontitis, indicating that\n                    <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                    UREA antibody levels are a protective factor against acute periodontitis.\n                  <\/jats:p>","DOI":"10.1177\/0265539x251400449","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T11:18:26Z","timestamp":1763378306000},"page":"123-131","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Causal relationship between Helicobacter pylori and periodontal disease: Two-sample Mendelian randomization study"],"prefix":"10.1177","volume":"43","author":[{"given":"Hong","family":"Wang","sequence":"first","affiliation":[{"name":"Anhui Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3530-0233","authenticated-orcid":false,"given":"Mei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Anhui Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,11,17]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.18-0289"},{"issue":"1","key":"e_1_3_5_3_1","first-page":"0393","article-title":"Helicobacter pylori in Periodontal Pockets and Saliva: A Possible Role in Gastric Infection Relapses","volume":"31","author":"Azzi L","year":"2017","unstructured":"Azzi L, Carinci F, Gabaglio S, et al. 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