{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T11:06:30Z","timestamp":1779188790273,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Community Dental Health"],"abstract":"<jats:p>\n                    Observational studies have consistently reported associations between oral lichen planus (OLP) and psychological distress, yet whether these relationships are causal remains uncertain. We performed a two-sample Mendelian randomization (MR) analysis to investigate the potential causal effects of depressive traits and anxiety-stress-related disorders (ASRD) on OLP. Genetic instruments for depressive traits (n = 500,199) and ASRD (n = 31,885) were obtained from the largest available genome-wide association study (GWAS) meta-analyses of European ancestry. Summary-level data for OLP were derived from the FinnGen R8 release, including 1,073 cases and 341,426 controls. Causal estimates were primarily calculated using the inverse-variance weighted (IVW) method, complemented by weighted median, MR-Egger, MR-PRESSO, leave-one-out analyses, and PhenoScanner searches to evaluate robustness and horizontal pleiotropy. The IVW results suggested a significant causal effect of ASRD on OLP risk (odds ratio 1.20, 95% CI 1.02\u20131.42), whereas no evidence supported a causal association between depressive traits and OLP (0.155 \u2264\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2264 0.694). Reverse MR analyses did not indicate that genetic liability to broad depression, major depressive disorder, or ASRD increased OLP risk (0.052 \u2264\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2264 0.793). Sensitivity analyses yielded consistent findings, and exclusion of pleiotropic SNPs did not materially alter the results. These findings support a potential causal role of ASRD in OLP pathogenesis and suggest that psychological factors related to stress and anxiety may warrant consideration in the clinical management of OLP.\n                  <\/jats:p>","DOI":"10.1177\/0265539x261429989","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T14:03:32Z","timestamp":1773237812000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Psychological distress and oral lichen planus: A bidirectional Mendelian randomization study"],"prefix":"10.1177","author":[{"given":"Wenhui","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Gao","sequence":"additional","affiliation":[{"name":"Xiangya Hospital, Central South 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