{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:04:17Z","timestamp":1789603457766,"version":"build-2803163510"},"reference-count":27,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Community Dental Health"],"abstract":"<jats:p>\n                    <jats:bold>Objective:<\/jats:bold>\n                    Evidence linking tooth loss to dementia is limited by cross-sectional designs and short follow-ups. This study examined the association between tooth loss and long-term dementia incidence in a nationwide cohort in the Republic of Korea, from a dental public health perspective.\n                    <jats:bold>Basic research design:<\/jats:bold>\n                    Observational cohort study.\n                    <jats:bold>Participants:<\/jats:bold>\n                    Data from 112,070 adults aged \u226540 years in the National Health Insurance Service\u2013Health Screening Cohort who completed general and oral health examinations in 2005\u20132006 and were followed for up to 15 years.\n                    <jats:bold>Main outcome measures:<\/jats:bold>\n                    Tooth loss was categorized as 0, 1\u20137, 8\u201314, or \u226515 missing teeth. Incident all-cause dementia, Alzheimer\u2019s disease, and vascular dementia were identified using diagnostic codes. Cox models estimated adjusted hazard ratios (aHRs) with sensitivity analyses requiring \u22652 diagnoses and subgroup analyses by sex and age.\n                    <jats:bold>Results:<\/jats:bold>\n                    Over a mean 13.5-year follow-up, 7616 participants (6.8%) developed dementia, with higher cumulative incidence observed across increasing levels of tooth loss. Higher aHRs were observed with increasing levels of tooth loss; participants with \u226515 missing teeth had the highest estimates (1 diagnosis: aHR 3.23, 95% CI 2.85\u20133.64; \u22652 diagnoses: aHR 2.01, 95% CI 1.77\u20132.28). Associations were similar for Alzheimer\u2019s disease and weaker for vascular dementia.\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Tooth loss was associated with higher long-term dementia risk, supporting its role as a potential population-level oral health indicator relevant to dental public health surveillance and prevention strategies.\n                  <\/jats:p>","DOI":"10.1177\/0265539x261450847","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T19:24:56Z","timestamp":1778095496000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Tooth loss and long-term dementia risk: A nationwide population-based cohort study in the Republic of Korea"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3459-6108","authenticated-orcid":false,"given":"Eun-Seo","family":"Jung","sequence":"first","affiliation":[{"name":"Korea University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,6]]},"reference":[{"key":"e_1_3_7_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm14090953"},{"key":"e_1_3_7_3_1","volume-title":"World Alzheimer Report 2021: Journey Through the Diagnosis of Dementia","author":"Alzheimer\u2019s Disease International","year":"2021","unstructured":"Alzheimer\u2019s Disease International (2021) World Alzheimer Report 2021: Journey Through the Diagnosis of Dementia. Alzheimer\u2019s Disease International."},{"key":"e_1_3_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.17978"},{"key":"e_1_3_7_5_1","volume-title":"National Institute of Dementia Annual Report 2022","author":"Central Dementia Center","year":"2022","unstructured":"Central Dementia Center (2022) National Institute of Dementia Annual Report 2022. Ministry of Health and Welfare."},{"key":"e_1_3_7_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.925398"},{"key":"e_1_3_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2025.105970"},{"key":"e_1_3_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1972.tb00899.x"},{"key":"e_1_3_7_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-018-1927-0"},{"key":"e_1_3_7_10_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2024.87"},{"key":"e_1_3_7_11_1","volume-title":"Multivariate Data Analysis","author":"Hair JF","year":"2006","unstructured":"Hair JF, Black WC, Babin BJ, et al. 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World Health Organization."},{"key":"e_1_3_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2023.04.021"}],"container-title":["Community Dental Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0265539X261450847","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0265539X261450847","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0265539X261450847","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T13:46:32Z","timestamp":1778247992000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0265539X261450847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,6]]},"references-count":27,"alternative-id":["10.1177\/0265539X261450847"],"URL":"https:\/\/doi.org\/10.1177\/0265539x261450847","relation":{},"ISSN":["0265-539X","2515-1746"],"issn-type":[{"value":"0265-539X","type":"print"},{"value":"2515-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,6]]},"article-number":"0265539X261450847"}}