{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T07:17:06Z","timestamp":1782803826505,"version":"3.54.5"},"reference-count":31,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Perfusion"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:p>\n                    Twenty (20) CPB-circuits were randomized to a CO\n                    <jats:sub>2<\/jats:sub>\n                    group or a control group. In the CO\n                    <jats:sub>2<\/jats:sub>\n                    group, each circuit was flushed with CO\n                    <jats:sub>2<\/jats:sub>\n                    (10L\/min) at the top of the venous reservoir for 5 minutes, after which priming fluid was added without interruption of the CO\n                    <jats:sub>2<\/jats:sub>\n                    inflow. Control group circuits were not flushed and contained air. A perfusionist, blinded to the study, started the pump (5L\/min), ventilated the oxygenator (3L O\n                    <jats:sub>2<\/jats:sub>\n                    \/min), and knocked on the oxygenator 20 times during the first and 14\n                    <jats:sup>th<\/jats:sup>\n                    minutes. Arterial line microemboli counts were registered with a Doppler for 15 minutes. In both groups, the median number of microemboli was highest during the first minute, 380.5 (288.75\/422.25, 25\n                    <jats:sup>th<\/jats:sup>\n                    \/75\n                    <jats:sup>th<\/jats:sup>\n                    percentile) counts in the control group versus 264.5 (171.75\/422.25) counts in the CO\n                    <jats:sub>2<\/jats:sub>\n                    group (p=0.01). Throughout the experiment, the median microembolic count minute by minute in the CO\n                    <jats:sub>2<\/jats:sub>\n                    group remained lower (p\u2264 0 .004) than in the control group. Knocking on the reservoir (14\n                    <jats:sup>th<\/jats:sup>\n                    minute) increased the microemboli counts in both groups (p&lt;0.01). The median values during the 15\n                    <jats:sup>th<\/jats:sup>\n                    minute were 15.5 and 0.5 in the control and the CO\n                    <jats:sub>2<\/jats:sub>\n                    groups, respectively, which were 9% (15.5\/173) and 0.5% (0.5\/87), respectively, of the values registered after 14 minutes. In conclusion, CO\n                    <jats:sub>2<\/jats:sub>\n                    flushing of the empty circuit decreases the number of gaseous emboli in the prime compared with a conventional circuit that contains air before being primed with fluid. Knocking of the oxygenator releases gaseous emboli and the duration of re-circulating the circuit with prime influences the number of microemboli.\n                  <\/jats:p>","DOI":"10.1177\/0267659109350241","type":"journal-article","created":{"date-parts":[[2009,10,28]],"date-time":"2009-10-28T21:23:25Z","timestamp":1256765005000},"page":"249-255","source":"Crossref","is-referenced-by-count":9,"title":["Does CO 2 flushing of the empty CPB circuit decrease the number of gaseous emboli in the prime?"],"prefix":"10.1177","volume":"24","author":[{"given":"J.","family":"Nyman","sequence":"first","affiliation":[{"name":"Karolinska Institutet, Department of Molecular Medicine and Surgery, Department of Cardiothoracic Surgery and Anesthesiology, Karolinska University Hospital, Stockholm, Sweden,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Rundby","sequence":"additional","affiliation":[{"name":"Karolinska Institutet, Department of Molecular Medicine and Surgery, Department of Cardiothoracic Surgery and Anesthesiology, Karolinska University Hospital, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Svenarud","sequence":"additional","affiliation":[{"name":"Karolinska Institutet, Department of Molecular Medicine and Surgery, Department of Cardiothoracic Surgery and Anesthesiology, Karolinska University Hospital, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"van der Linden","sequence":"additional","affiliation":[{"name":"Karolinska Institutet, Department of Molecular Medicine and Surgery, Department of Cardiothoracic Surgery and Anesthesiology, Karolinska University Hospital, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2009,10,28]]},"reference":[{"key":"atypb1","unstructured":"Lindsay B. 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