{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:04:03Z","timestamp":1777917843214,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2010,12,22]],"date-time":"2010-12-22T00:00:00Z","timestamp":1292976000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perfusion"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:p>Introduction: Balanced colloidal priming solutions are supposed to further minimize the effects of cardiopulmonary bypass (CPB) on haemostasis as compared to gelatin-based preparations. This exploratory study investigated whether clot formation, in particular the fibrin part of the clot, is less altered by a modern balanced HES solution as compared to a gelatin-based priming solution.<\/jats:p>\n                  <jats:p>Methods: CPB priming solutions containing 60% gelatin (Gelofusin\u00ae) or balanced HES starch (100% or 60% Tetraspan\u00ae) were mixed with blood samples from healthy volunteers and compared with respect to their impact on clotting time (CT), alpha angle, maximum clot firmness (MCF), and fibrinogen, using thromboelastometry.<\/jats:p>\n                  <jats:p>Results: The 100% and 60% HES priming solutions significantly increased the EXTEM CT from 66 \u00b1 9 s to 82 \u00b1 19 and 83 \u00b1 13, respectively (both P&lt;0.05 vs. baseline). The speed of solid clot formation decreased significantly for all priming solutions compared with baseline values. The INTEM MCF decreased from 59 \u00b1 4 mm to 47 \u00b1 4, 44 \u00b1 4 and 43 \u00b1 3 mm, whereas the EXTEM MCF decreased from 57 \u00b1 4 mm to 51 \u00b1 4, 51 \u00b1 4 and 50 \u00b1 4 mm after dilution with 60% gelatin, 100% HES or 60% HES priming solution, respectively (all P&lt;0.01 vs. baseline). The priming solutions containing HES induced the largest decrease in MCF attributed to fibrinogen from 12 \u00b1 3 mm to 4 \u00b1 4 mm and 3 \u00b1 2 mm (both P&lt;0.05) for the 100% and mixed priming solution, respectively.<\/jats:p>\n                  <jats:p>Conclusions: Ex vivo rotation thromboelastometry did not reveal the expected preservation of coagulation parameters, in particular the fibrin part of clot formation, by a balanced HES priming solution.<\/jats:p>","DOI":"10.1177\/0267659110394711","type":"journal-article","created":{"date-parts":[[2010,12,22]],"date-time":"2010-12-22T20:49:35Z","timestamp":1293050975000},"page":"175-180","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["The impact of balanced hydroxylethyl starch cardiopulmonary bypass priming solution on the fibrin part of clot formation: ex vivo rotation thromboelastometry"],"prefix":"10.1177","volume":"26","author":[{"given":"Marly H","family":"Appelman","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lerau J M","family":"van Barneveld","sequence":"additional","affiliation":[{"name":"Department of Cardio-thoracic Surgery, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes W A","family":"Romijn","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander B A","family":"Vonk","sequence":"additional","affiliation":[{"name":"Department of Cardio-thoracic Surgery, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christa","family":"Boer","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, the Netherlands,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,12,22]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)38727-6"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2004.11.046"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1020309"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeq084"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1191\/0267659102pf538oa"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1053\/jcan.2001.23276"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000175216.53374.27"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(01)02745-X"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(10)60908-3"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)39512-1"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(10)60683-2"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2009.10.018"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000200285.20510.b6"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2005.00619.x"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e31818c1282"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2009.09.014"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeq173"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1097\/01.mbc.0000169225.31173.19"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aef242"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2008.01901.x"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-200004000-00005"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03460.x"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000073353.31894.BE"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2009.07.038"}],"container-title":["Perfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0267659110394711","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0267659110394711","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:24:21Z","timestamp":1777659861000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0267659110394711"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,22]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,5]]}},"alternative-id":["10.1177\/0267659110394711"],"URL":"https:\/\/doi.org\/10.1177\/0267659110394711","relation":{},"ISSN":["0267-6591","1477-111X"],"issn-type":[{"value":"0267-6591","type":"print"},{"value":"1477-111X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,22]]}}}