{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:05:16Z","timestamp":1777917916737,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2012,12,20]],"date-time":"2012-12-20T00:00:00Z","timestamp":1355961600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perfusion"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Given that micelles of lipids are colloids, the hypothesis was generated that the rapid administration of large volumes of soybean oil micelles would be an effective perfusion fluid. We also hypothesized that oxygen loading would be enhanced due to the greater solubility of oxygen in lipids compared to water.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A 100% lethal mouse model of blood loss was used to compare the ability of soybean oil micelles to that of Ringer\u2019s lactate, blood and other fluids, with respect to raising and maintaining the blood pressure for one hour. Oxygen on- and off-loading of various concentrations of soybean oil micelles was determined using mass spectroscopy. Nitric oxide uptake by micelles was also determined in a similar fashion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A 20% soybean oil emulsion was superior to Ringer\u2019s lactate in raising and maintaining blood pressure. A 20% soybean oil emulsion with 5% albumin added was superior to shed blood as well as solutions comprised of 5% albumin added to either normal saline or Ringer\u2019s lactate. There was a linear relationship between oxygen content and micelle concentration between 10% and 30%. Off-loading of oxygen from the micelles was nearly as fast as off-loading from water. Nitric oxide also loaded preferentially onto soybean oil micelles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>(1) Soybean oil emulsions were superior to other fluids in restoring and maintaining the blood pressure; (2) oxygen-carrying ability of soybean oil micelles exceeds that of water and follows Henry\u2019s law between 10% and 30% w\/v oil content; (3) nitric oxide was carried by the micelles; (4) animals receiving soybean oil micelles did not exhibit fat embolization; (5) colloids comprised of soybean oil-containing micelles may be used to replace blood loss and may be used to deliver oxygen and other potentially therapeutic gases such as nitric oxide to tissues.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0267659112469643","type":"journal-article","created":{"date-parts":[[2012,12,22]],"date-time":"2012-12-22T01:15:30Z","timestamp":1356138930000},"page":"160-166","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Soybean oil: a potentially new intravascular perfusate"],"prefix":"10.1177","volume":"28","author":[{"given":"M","family":"Armbruster","sequence":"first","affiliation":[{"name":"University of Florida College of Medicine, Gainesville, FL, USA"},{"name":"Department of Chemical and Biomolecular Engineering, Tulane University, New Orleans, LA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Grimley","sequence":"additional","affiliation":[{"name":"Department of Physics, Centenary College of Louisiana, Shreveport, LA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Physics, Centenary College of Louisiana, Shreveport, LA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Nacionales","sequence":"additional","affiliation":[{"name":"University of Florida College of Medicine, Gainesville, FL, USA"},{"name":"Department of Surgery, University of Florida College of Medicine, Gainesville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Efron","sequence":"additional","affiliation":[{"name":"University of Florida College of Medicine, Gainesville, FL, USA"},{"name":"Department of Surgery, University of Florida College of Medicine, Gainesville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Moldawer","sequence":"additional","affiliation":[{"name":"University of Florida College of Medicine, Gainesville, FL, USA"},{"name":"Department of Surgery, University of Florida College of Medicine, Gainesville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Papadopoulos","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering, Tulane University, New Orleans, LA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Ungaro","sequence":"additional","affiliation":[{"name":"University of Florida College of Medicine, Gainesville, FL, USA"},{"name":"Department of Surgery, University of Florida College of Medicine, Gainesville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Cuenca","sequence":"additional","affiliation":[{"name":"University of Florida College of Medicine, Gainesville, FL, USA"},{"name":"Department of Surgery, University of Florida College of Medicine, Gainesville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Simpkins","sequence":"additional","affiliation":[{"name":"Vivacelle Bio, Shreveport, LA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,12,20]]},"reference":[{"key":"bibr1-0267659112469643","doi-asserted-by":"publisher","DOI":"10.1021\/jf9908188"},{"key":"bibr2-0267659112469643","first-page":"227","volume":"1110","author":"Liu SL","year":"2008","journal-title":"Zhongguo Wei Zhong Bing Ji Jiu Yi Xue"},{"key":"bibr3-0267659112469643","first-page":"663","volume":"38","author":"Liu SL","year":"2007","journal-title":"Sichuan Da Xue Xue Bao Yi Xue Ban"},{"key":"bibr4-0267659112469643","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2006.08.014"},{"key":"bibr5-0267659112469643","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.104.047746"},{"key":"bibr6-0267659112469643","doi-asserted-by":"publisher","DOI":"10.1097\/01.TA.0000112933.83144.23"},{"key":"bibr7-0267659112469643","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2008.09.059"},{"key":"bibr8-0267659112469643","first-page":"3968","volume-title":"United States Pharmacopeia","year":"2007"},{"key":"bibr9-0267659112469643","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2009.017"},{"key":"bibr10-0267659112469643","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2425"},{"key":"bibr11-0267659112469643","unstructured":"Rochette L, Cottin Y, Vergely C. Carbon monoxide: mechanisms of action and potential clinical implications. Pharmacol Ther 2012 Sep 29 epub ahead of print http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23026155t"},{"key":"bibr12-0267659112469643","first-page":"387","volume":"78","author":"Jordan BD","year":"2010","journal-title":"AANA J"},{"key":"bibr13-0267659112469643","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.29.855"},{"key":"bibr14-0267659112469643","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04230.x"},{"key":"bibr15-0267659112469643","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198211000-00008"}],"container-title":["Perfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0267659112469643","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0267659112469643","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0267659112469643","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:26:09Z","timestamp":1777659969000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0267659112469643"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,20]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1177\/0267659112469643"],"URL":"https:\/\/doi.org\/10.1177\/0267659112469643","relation":{},"ISSN":["0267-6591","1477-111X"],"issn-type":[{"value":"0267-6591","type":"print"},{"value":"1477-111X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,20]]}}}