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In animal experiments investigating CPR with ECLS, systemic anticoagulation before induced cardiac arrest is normal, but a major point of dispute, since preliminary heparinization in patients undergoing unwitnessed cardiac arrest is impossible. In this study, we investigated options for ECLS after an experimental 15 minutes normothermic cardiac arrest, without preceding anticoagulation, in pigs. Neurological recovery was assessed by a scoring system, electroencephalography and brain magnetic resonance imaging. Additionally, brain histology was performed on day seven after cardiac arrest. We demonstrated that preliminary heparin administration was not necessary for survival or neurological recovery in this setting. Heparin flushing of the cannulae seemed sufficient to avoid thrombus formation. These findings may ease the way to using ECLS in patients with sudden cardiac arrest.<\/jats:p>","DOI":"10.1177\/0267659113495081","type":"journal-article","created":{"date-parts":[[2013,7,5]],"date-time":"2013-07-05T00:23:03Z","timestamp":1372983783000},"page":"520-528","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Prolonged cardiac arrest and resuscitation by extracorporeal life support: favourable outcome without preceding anticoagulation in an experimental setting"],"prefix":"10.1177","volume":"28","author":[{"given":"K","family":"Foerster","sequence":"first","affiliation":[{"name":"Heart Center Freiburg University, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"D\u2019Inka","sequence":"additional","affiliation":[{"name":"Heart Center Freiburg University, Freiburg, 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