{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T06:47:22Z","timestamp":1782456442074,"version":"3.54.5"},"reference-count":43,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2013,11,8]],"date-time":"2013-11-08T00:00:00Z","timestamp":1383868800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perfusion"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Cardiopulmonary bypass surgery is associated with a systemic inflammatory response through the interaction of air, blood and synthetic components in the bypass system and the physical trauma of surgery. An alternative cardiopulmonary bypass system, minimal extracorporeal circulation (MECC), has shown promising results in terms of reducing the inflammatory response. We hypothesized that this system may reduce pathological excessive scarring. To study this assumption, the effects of MECC and the effects of conventional extracorporeal circulation (CECC) with dexamethasone on skin scarring were compared in a standardized wound-healing model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results:<\/jats:title>\n                    <jats:p>Pre-sternal scars were evaluated prospectively at four and 12 months postoperatively. The height and width of the scars were measured, using a slide caliper and sonography. The scars were scored using the validated Patient and Observer Scar Assessment Scale. Additional risk factors for hypertrophic scar formation were identified by means of a questionnaire. During surgery, MECC was used in 45 patients and CECC\/dexamethasone in 42 patients. Four months postoperatively, 22 patients of the MECC group (49%) and 18 patients in the CECC\/dexamethasone group (43%) had developed hypertrophic scars. Twelve months postoperatively, the hypertrophic scars in four patients of the MECC group and in two patients of the CECC\/dexamethasone group had become normotrophic. In 18 patients of the MECC group (38%) and 16 patients of the CECC group (41%) the scars remained hypertrophic at 12 months. These differences between the two groups were not statistically significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>MECC does not reduce hypertrophic scar formation compared with CECC with dexamethasone, but its use is more beneficial than the use of CECC\/dexamethasone because of the circulatory and immunological advantages and because treatment with dexamethasone can be omitted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0267659113511656","type":"journal-article","created":{"date-parts":[[2013,11,8]],"date-time":"2013-11-08T23:40:29Z","timestamp":1383954029000},"page":"249-259","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Minimal extracorporeal circulation (MECC) does not result in less hypertrophic scar formation as compared to conventional extracorporeal circulation (CECC) with dexamethasone"],"prefix":"10.1177","volume":"29","author":[{"given":"EA","family":"Soykan","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, VU University Medical Centre, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Butzelaar","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, VU University Medical Centre, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TL","family":"de Kroon","sequence":"additional","affiliation":[{"name":"Department of Cardio-Thoracic Surgery, Saint Antonius Hospital, Nieuwegein, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RHJ","family":"Beelen","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell Biology and Immunology, VU University Medical Centre, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MMW","family":"Ulrich","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, VU University Medical Centre, Amsterdam, the Netherlands"},{"name":"Association of Dutch Burn Centres, Beverwijk, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AB","family":"Mink van der Molen","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Saint Antonius Hospital, Nieuwegein, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FB","family":"Niessen","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, VU University Medical Centre, Amsterdam, the 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