{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:06:07Z","timestamp":1777917967637,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2014,1,21]],"date-time":"2014-01-21T00:00:00Z","timestamp":1390262400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perfusion"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Great Ormond Street Children\u2019s Hospital undertakes over 500 open heart cardiothoracic procedures requiring cardiopulmonary bypass per year. Data from our centre show that many of our neonatal\/paediatric patients require higher cardiac indexes than previously thought. We evaluated the new Pixie\u2122 oxygenation system, rated from 0.1 L\/min to 2 L\/min, to determine if it could be used for these patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Between 2010 and 2012, 250 Pixie\u2122 oxygenators were used on consecutive patients requiring correction of congenital cardiac defects. Data were collected on F\n                      <jats:sub>i<\/jats:sub>\n                      O\n                      <jats:sub>2<\/jats:sub>\n                      requirements, oxygenator pressure drop and gaseous microemboli handling. Retrospective analysis was also undertaken on the procedures and demographics of all patients during 2011-2012 to determine the percentage of patients on whom the Pixie\u2122 could be used.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Analysis of the procedures undertaken at Great Ormond Street Hospital (GOSH) showed that 89% were in patients under 20 kg, requiring a flow rate of &lt;2 L\/min (at a base cardiac index of 2.8 L\/min\/m\n                      <jats:sup>2<\/jats:sup>\n                      ). The maximum F\n                      <jats:sub>i<\/jats:sub>\n                      O\n                      <jats:sub>2<\/jats:sub>\n                      required at 2.5 L\/min was 85%. Gaseous microemboli were reduced by 82.5\u00b19.9% and bubble volume was decreased by 94.3\u00b18.4% from the \u2018venous\u2019 pre-oxygenator to the \u2018arterial\u2019 post-oxygenator.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>The Pixie\u2122 oxygenator proved effective at flows up to 2.5 L\/min, with air-handling capabilities comparable with other oxygenators. This represents a single oxygenator that could potentially be used to cover 89% of our surgical procedures. However, we believe that, for the smallest patients (i.e. &lt; 2kg), a smaller priming oxygenator should be used in order to limit unnecessary haemodilution in this vulnerable group.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0267659114521101","type":"journal-article","created":{"date-parts":[[2014,1,21]],"date-time":"2014-01-21T22:29:18Z","timestamp":1390343358000},"page":"194-198","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical experience with Affinity Pixie\u2122 oxygenation system in paediatric and infant patients"],"prefix":"10.1177","volume":"29","author":[{"given":"R","family":"Issitt","sequence":"first","affiliation":[{"name":"Department of Clinical Perfusion Great Ormond Street Children\u2019s Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Robertson","sequence":"additional","affiliation":[{"name":"Department of Clinical Perfusion Great Ormond Street Children\u2019s Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Cross","sequence":"additional","affiliation":[{"name":"Department of Clinical Perfusion Great Ormond Street Children\u2019s Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Crook","sequence":"additional","affiliation":[{"name":"Department of Clinical Perfusion Great Ormond Street Children\u2019s Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Molyneux","sequence":"additional","affiliation":[{"name":"Department of Clinical Perfusion Great Ormond Street Children\u2019s Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Shaw","sequence":"additional","affiliation":[{"name":"Department of Clinical Perfusion Great Ormond Street Children\u2019s Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Walton","sequence":"additional","affiliation":[{"name":"Department of Clinical Perfusion Great Ormond Street Children\u2019s Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Tsang","sequence":"additional","affiliation":[{"name":"Department of Paediatric Cardiothoracic Surgery, Great Ormond Street Children\u2019s Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,1,21]]},"reference":[{"key":"bibr1-0267659114521101","doi-asserted-by":"publisher","DOI":"10.1177\/026765919000500102"},{"key":"bibr2-0267659114521101","doi-asserted-by":"publisher","DOI":"10.1177\/026765919901400104"},{"key":"bibr3-0267659114521101","doi-asserted-by":"publisher","DOI":"10.1191\/0267659103pf686oa"},{"key":"bibr4-0267659114521101","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(01)01099-5"},{"key":"bibr5-0267659114521101","doi-asserted-by":"publisher","DOI":"10.1177\/026765919300800114"},{"key":"bibr6-0267659114521101","doi-asserted-by":"publisher","DOI":"10.1177\/0267659111430560"},{"key":"bibr7-0267659114521101","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2009.00895.x"},{"key":"bibr8-0267659114521101","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2003.08.033"},{"key":"bibr9-0267659114521101","first-page":"271","volume":"39","author":"De Somer F","year":"2007","journal-title":"J Extra Corpor Technol"},{"key":"bibr10-0267659114521101","doi-asserted-by":"publisher","DOI":"10.1510\/icvts.2009.229088"},{"key":"bibr11-0267659114521101","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevBiomedEng.v33.i4.10"}],"container-title":["Perfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0267659114521101","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0267659114521101","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0267659114521101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:27:48Z","timestamp":1777660068000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0267659114521101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,21]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1177\/0267659114521101"],"URL":"https:\/\/doi.org\/10.1177\/0267659114521101","relation":{},"ISSN":["0267-6591","1477-111X"],"issn-type":[{"value":"0267-6591","type":"print"},{"value":"1477-111X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,21]]}}}