{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:26:19Z","timestamp":1777915579869,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2014,5,19]],"date-time":"2014-05-19T00:00:00Z","timestamp":1400457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perfusion"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Excessive hemodilution during cardiopulmonary bypass (CPB) is associated with an increased rate of red blood cell (RBC) transfusion and acute kidney injury (AKI). Minimization of the oxygenator priming volume is a measure to contain hemodilution. In this study, we evaluated the new oxygenator, Sorin Inspire 6\u2122, with respect to its ability to limit hemodilution, RBC transfusion rate and postoperative AKI rate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A retrospective study on a consecutive series of 1,724 adult patients receiving heart surgery with CPB. Patients treated with the Inspire 6\u2122 were assigned to the low priming volume oxygenator (LPVO) group (N=383) and patients treated with conventional oxygenators to the conventional group (N=1,341). Dynamic priming volume, time course of the hematocrit, RBC transfusions and AKI rate were compared between the groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Priming volume was significantly (p=0.001) lower in the LPVO group (624\u00b1113 mL) vs. the conventional group (775\u00b1150 mL), with higher values of hematocrit during and after CPB. After correction for other confounders, patients in the LPVO group had a significantly lower RBC transfusion rate (odds ratio 0.68, 95% confidence interval 0.52-0.90, p=0.006) and AKI rate (odds ratio 0.55, 95% confidence interval 0.32-0.93, p=0.032).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The Inspire 6\u2122 oxygenator allows a significant containment of hemodilution during CPB, reducing the risk of RBC transfusions and postoperative AKI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0267659114535649","type":"journal-article","created":{"date-parts":[[2014,5,19]],"date-time":"2014-05-19T23:36:31Z","timestamp":1400542591000},"page":"120-126","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["Effects of priming volume reduction on allogeneic red blood cell transfusions and renal outcome after heart surgery"],"prefix":"10.1177","volume":"30","author":[{"given":"M","family":"Ranucci","sequence":"first","affiliation":[{"name":"Departments of Cardiothoracic - Vascular Anesthesia and Intensive Care, IRCCS Policlinico San Donato, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Pistuddi","sequence":"additional","affiliation":[{"name":"Departments of Cardiothoracic - Vascular Anesthesia and Intensive Care, IRCCS Policlinico San Donato, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Carboni","sequence":"additional","affiliation":[{"name":"Departments of Cardiovascular Perfusion, IRCCS Policlinico San Donato, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Cotza","sequence":"additional","affiliation":[{"name":"Departments of Cardiovascular Perfusion, IRCCS Policlinico San Donato, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Ditta","sequence":"additional","affiliation":[{"name":"Departments of Cardiovascular Perfusion, IRCCS Policlinico San Donato, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Boncilli","sequence":"additional","affiliation":[{"name":"Departments of Cardiovascular Perfusion, IRCCS Policlinico San Donato, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Brozzi","sequence":"additional","affiliation":[{"name":"Departments of Cardiovascular Perfusion, IRCCS Policlinico San Donato, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Pelissero","sequence":"additional","affiliation":[{"name":"Scientific Directorate, IRCCS Policlinico San Donato, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the Surgical and Clinical Outcome Research (SCORE) Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,5,19]]},"reference":[{"key":"bibr1-0267659114535649","doi-asserted-by":"publisher","DOI":"10.1177\/026765919400900503"},{"key":"bibr2-0267659114535649","first-page":"194","volume":"96","author":"Fang WC","year":"1997","journal-title":"Circulation"},{"key":"bibr3-0267659114535649","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(02)73291-1"},{"key":"bibr4-0267659114535649","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(03)00558-7"},{"key":"bibr5-0267659114535649","doi-asserted-by":"publisher","DOI":"10.1378\/chest.119.5.1461"},{"key":"bibr6-0267659114535649","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000217920.48559.D8"},{"key":"bibr7-0267659114535649","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2005.12.037"},{"key":"bibr8-0267659114535649","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa070403"},{"key":"bibr9-0267659114535649","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2012.04.042"},{"key":"bibr10-0267659114535649","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2010.11.078"},{"key":"bibr11-0267659114535649","author":"Ranucci M","year":"2013","journal-title":"Minerva 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