{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:26:22Z","timestamp":1777915582022,"version":"3.51.4"},"reference-count":6,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2014,6,4]],"date-time":"2014-06-04T00:00:00Z","timestamp":1401840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perfusion"],"published-print":{"date-parts":[[2015,4]]},"abstract":"A month-old baby girl with blood type O positive received a donor heart organ from a donor with blood type B. This was the first institutional ABO-incompatible heart transplant.<\/jats:p>\n \n Infants listed for transplantation may be considered for an ABO-incompatible heart transplant based on their antibody levels and age. The United Network of Organ Sharing (UNOS) protocol is infants under 24 months with titers less than or equal to 1:4.\n 1<\/jats:sup>\n <\/jats:p>\n \n This recipient\u2019s anti-A and anti-B antibodies were monitored with titer assays to determine their levels; antibody levels less than 1:4 are acceptable pre-transplant in order to proceed with donor and transplant arrangements.\n 1<\/jats:sup>\n Immediately prior to initiating cardiopulmonary bypass (CPB), a complete whole body exchange transfusion of at least two-times the patient\u2019s circulating blood volume was performed with packed red blood cells (pRBC), fresh frozen plasma (FFP) and 25% albumin. Titer assays were sent two minutes after initiation of full CPB and then hourly until the cross-clamp was removed. Institutionally, reperfusion of the donor heart is not restored until the antibody level from the titer assay is known and reported as less than 1:4; failing to achieve an immulogically tolerant recipient will provide conditions for hyperacute rejection. The blood collected during the transfusion exchange was immediately processed through a cell saver so the pRBC\u2019s could be re-infused to the patient during CPB, as necessary. The remainder of the transplant was performed in the same fashion as an ABO-compatible heart transplant. The patient has shown no signs of rejection following transplantation.\n <\/jats:p>","DOI":"10.1177\/0267659114538895","type":"journal-article","created":{"date-parts":[[2014,6,4]],"date-time":"2014-06-04T20:41:20Z","timestamp":1401914480000},"page":"209-212","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["ABO-incompatible heart transplants"],"prefix":"10.1177","volume":"30","author":[{"given":"M","family":"Hageman","sequence":"first","affiliation":[{"name":"Vanderbilt University Medical Center Cardiovascular Perfusion Technology Program, Nashville, Tennessee, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Michaud","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center Cardiovascular Perfusion Technology Program, Nashville, Tennessee, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Chinnappan","sequence":"additional","affiliation":[{"name":"Monroe Carell Jr. Children\u2019s Hospital at Vanderbilt, Nashville, Tennessee, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Klein","sequence":"additional","affiliation":[{"name":"Monroe Carell Jr. Children\u2019s Hospital at Vanderbilt, Nashville, Tennessee, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Mettler","sequence":"additional","affiliation":[{"name":"Monroe Carell Jr. Children\u2019s Hospital at Vanderbilt, Nashville, Tennessee, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,6,4]]},"reference":[{"key":"bibr1-0267659114538895","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/j.1600-6143.2007.02040.x","volume":"8","author":"Roche SL","year":"2008","journal-title":"Am J Transplant"},{"key":"bibr2-0267659114538895","doi-asserted-by":"publisher","DOI":"10.1191\/0267659104pf708oa"},{"key":"bibr3-0267659114538895","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200103153441102"},{"key":"bibr4-0267659114538895","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.03.007"},{"key":"bibr5-0267659114538895","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02934.x"},{"key":"bibr6-0267659114538895","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2008.07.001"}],"container-title":["Perfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0267659114538895","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0267659114538895","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0267659114538895","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T17:24:23Z","timestamp":1777656263000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0267659114538895"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,4]]},"references-count":6,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1177\/0267659114538895"],"URL":"https:\/\/doi.org\/10.1177\/0267659114538895","relation":{},"ISSN":["0267-6591","1477-111X"],"issn-type":[{"value":"0267-6591","type":"print"},{"value":"1477-111X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,4]]}}}