{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:28:05Z","timestamp":1777915685180,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2017,10,6]],"date-time":"2017-10-06T00:00:00Z","timestamp":1507248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perfusion"],"published-print":{"date-parts":[[2018,4]]},"abstract":"\n Background:<\/jats:title>\n Modified ultrafiltration (MUF) can be performed in infants with ventricular septal defects (VSDs) after cardiopulmonary bypass (CPB) to reduce haemodilution and its potential adverse effects. High-flow MUF might reduce ultrafiltration duration and hasten the necessary correction of haemodilution during CPB. However, its influence on brain oxygenation remains controversial.<\/jats:p>\n <\/jats:sec>\n \n Objective:<\/jats:title>\n This non-randomized, prospective, pilot study aimed to investigate the influence of high-flow MUF on brain oxygenation in infants with VSDs.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n High-flow MUF (\u226520 mL\/kg\/min) was performed in twenty infants. Brain oxygen saturation (rSO\n 2<\/jats:sub>\n ) and tissue haemoglobin index (tHI) were non-invasively and continuously measured intraoperatively using near-infrared spectroscopy (NIRS). Transcranial Doppler non-invasively detected the mean flow velocity of the middle cerebral artery (Vmean).\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n rSO\n 2<\/jats:sub>\n increased significantly during MUF, as did tHI, Vmean, mean arterial pressure and haematocrit (all p<0.05). No correlation was found between changes in rSO\n 2<\/jats:sub>\n and changes in other parameters (all p\u22650.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n In infants with ventricular septal defects managed with CPB during VSDs repair, high-flow MUF did not reduce brain oxygenation.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/0267659117736120","type":"journal-article","created":{"date-parts":[[2017,10,7]],"date-time":"2017-10-07T00:52:20Z","timestamp":1507337540000},"page":"203-208","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Influence of high-flow modified ultrafiltration on brain oxygenation and perfusion during surgery for children with ventricular septal defects: a pilot study"],"prefix":"10.1177","volume":"33","author":[{"given":"Zaishen","family":"Jia","sequence":"first","affiliation":[{"name":"Department of Extracorporeal Circulation, Centre for Cardiac Intensive Care, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Disease, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yichao","family":"Teng","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Medical School, Tsinghua University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Extracorporeal Circulation, Centre for Cardiac Intensive Care, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Disease, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Extracorporeal Circulation, Centre for Cardiac Intensive Care, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Disease, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Medical School, Tsinghua University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaotong","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Extracorporeal Circulation, Centre for Cardiac Intensive Care, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Disease, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,10,6]]},"reference":[{"key":"bibr1-0267659117736120","first-page":"422","volume":"84","author":"Naik 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