{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:28:34Z","timestamp":1777915714795,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Brightwake Ltd"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perfusion"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Cardiac surgery using cardiopulmonary bypass (CPB) is associated with a coagulopathy due to haemodilution, thrombocytopenia and platelet dysfunction and the activation of coagulation and fibrinolysis, despite the use of large doses of unfractionated heparin. Conventional red cell salvage may exacerbate post-operative bleeding as plasma containing haemostatic factors is discarded. We hypothesized that a novel cell salvage device (HemoSep) may attenuate haemostatic changes associated with red cell salvage. We studied haemostatic markers following autologous transfusion from conventional cell salvage or the HemoSep device.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This randomised, controlled trial compared haemostatic markers in patients undergoing coronary artery bypass grafting or aortic valve replacement who received autologous blood returned from cell salvage (control) or HemoSep (study). Blood samples were taken pre-operatively, end of CPB, post-transfusion of salvaged blood and 3 hours post-operatively and analysed for full blood count (FBC), prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen, D-dimer and endogenous thrombin potential (ETP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Fifty-four patients were recruited (n=28 control, n=26 study). Processed blood volume for transfusion was significantly (p&lt;0.001) higher in the HemoSep group. In the HemoSep group, the PT was shorter (18.7\u00b10.3 vs 19.9\u00b10.3 sec; p&lt;0.05) post-operatively and the aPTT was longer (48.6\u00b13.8 vs 37.3\u00b11.0 sec; p&lt;0.01) following autologous transfusion. In the control group, D-dimer and ETP levels were higher (1903\u00b1424 vs.1088\u00b1151; p&lt;0.05 and 739\u00b146 vs. 394\u00b160; p&lt;0.001, respectively) following autologous transfusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Although centrifuged cell salvage is known to adequately haemoconcentrate and remove unwanted substrates and bacteriological contamination, the process can exacerbate coagulopathy. The HemoSep device demonstrated some increase in haemostatic markers when used in low-risk cardiac surgery patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0267659118789051","type":"journal-article","created":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T10:24:35Z","timestamp":1533119075000},"page":"76-83","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["A comparison of haemostatic biomarkers during low-risk patients undergoing cardiopulmonary bypass using either conventional centrifugal cell salvage or the HemoSep device"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4979-0376","authenticated-orcid":false,"given":"Gethin","family":"Boyle","sequence":"first","affiliation":[{"name":"Clinical Perfusion Department, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust, St Thomas\u2019 Hospital, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"Kuffel","sequence":"additional","affiliation":[{"name":"Thrombosis & Vascular Biology Group, The Rayne Institute, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiran","family":"Parmar","sequence":"additional","affiliation":[{"name":"Thrombosis & Vascular Biology Group, The Rayne Institute, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsty","family":"Gibson","sequence":"additional","affiliation":[{"name":"Cardiovascular Research, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust, St Thomas\u2019 Hospital, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan","family":"Smith","sequence":"additional","affiliation":[{"name":"Cardiovascular Research, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust, St Thomas\u2019 Hospital, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aidan","family":"Grehan","sequence":"additional","affiliation":[{"name":"Clinical Perfusion Department, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust, St Thomas\u2019 Hospital, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beverley J","family":"Hunt","sequence":"additional","affiliation":[{"name":"Thrombosis & Vascular Biology Group, The Rayne Institute, UK"},{"name":"Thrombosis & Haemophilia, Guy\u2019s & St Thomas\u2019 NHS Foundation Trust, St Thomas\u2019 Hospital, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J","family":"Chambers","sequence":"additional","affiliation":[{"name":"Cardiothoracic Surgery\/Cardiac Surgical Research, The Rayne Institute, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust, St Thomas\u2019 Hospital, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,8,1]]},"reference":[{"key":"bibr1-0267659118789051","unstructured":"NICE, 2014. NICE recommends new tests for bleeding problems during and after cardiac surgery [online] Available at: http:\/\/www.nice.org.uk\/news\/press-and-media\/nice-recommends-new-tests-for-bleeding-problems-during-and-after-cardiac-surgery [Accessed: 19th April 2015]"},{"key":"bibr2-0267659118789051","doi-asserted-by":"publisher","DOI":"10.1191\/0267659105pf831oa"},{"key":"bibr3-0267659118789051","doi-asserted-by":"publisher","DOI":"10.1177\/0267659111399951"},{"key":"bibr4-0267659118789051","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2013.03.048"},{"key":"bibr5-0267659118789051","doi-asserted-by":"publisher","DOI":"10.1111\/anae.13019"},{"key":"bibr6-0267659118789051","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.04146.x"},{"key":"bibr7-0267659118789051","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.02028.x"},{"key":"bibr8-0267659118789051","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2008.12.097"},{"key":"bibr9-0267659118789051","doi-asserted-by":"publisher","DOI":"10.1177\/0267659112442236"},{"key":"bibr10-0267659118789051","doi-asserted-by":"publisher","DOI":"10.1191\/0267659103pf647oa"},{"key":"bibr11-0267659118789051","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e31818657a3"},{"key":"bibr12-0267659118789051","doi-asserted-by":"publisher","DOI":"10.1191\/0267659102pf603oa"}],"container-title":["Perfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0267659118789051","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0267659118789051","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0267659118789051","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T17:27:31Z","timestamp":1777656451000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0267659118789051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,1]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1177\/0267659118789051"],"URL":"https:\/\/doi.org\/10.1177\/0267659118789051","relation":{},"ISSN":["0267-6591","1477-111X"],"issn-type":[{"value":"0267-6591","type":"print"},{"value":"1477-111X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,1]]}}}