{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:58:10Z","timestamp":1792799890894,"version":"4.5.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T00:00:00Z","timestamp":1532908800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"The Western Norway Regional Health Authority","id":[{"id":"https:\/\/ror.org\/001212e83","id-type":"ROR","asserted-by":"crossref"}]},{"name":"The Grieg Foundation","id":[{"id":"https:\/\/ror.org\/0587zpn52","id-type":"ROR","asserted-by":"crossref"}]},{"name":"The Norwegian Health Association"},{"name":"The Bergen University Heart Fund"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perfusion"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>\n                      This experimental study compares myocardial function after prolonged arrest by St. Thomas\u2019 Hospital polarizing cardioplegic solution (esmolol, adenosine, Mg\n                      <jats:sup>2+<\/jats:sup>\n                      ) with depolarizing (hyperkalaemic) St. Thomas\u2019 Hospital No 2, both administered as cold oxygenated blood cardioplegia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Twenty anaesthetized pigs on tepid (34\u00b0C) cardiopulmonary bypass (CPB) were randomised to cardioplegic arrest for 120 min with antegrade, repeated, cold, oxygenated, polarizing (STH-POL) or depolarizing (STH-2) blood cardioplegia every 20 min. Cardiac function was evaluated at Baseline and 60, 150 and 240 min after weaning from CPB, using a pressure-conductance catheter and epicardial echocardiography. Regional tissue blood flow, cleaved caspase-3 activity and levels of malondialdehyde were evaluated in myocardial tissue samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Preload recruitable stroke work (PRSW) was increased after polarizing compared to depolarizing cardioplegia 150 min after declamping (73.0\u00b13.2 vs. 64.3\u00b12.4 mmHg, p=0.047). Myocardial tissue blood flow rate was high in both groups compared to the Baseline levels and decreased significantly in the STH-POL group only, from 60 min to 150 min after declamping (p&lt;0.005). Blood flow was significantly reduced in the STH-POL compared to the STH-2 group 240 min after declamping (p&lt;0.05). Left ventricular mechanical efficiency, the ratio between total pressure-volume area and blood flow rate, gradually decreased after STH-2 cardioplegia and was significantly reduced compared to STH-POL cardioplegia after 150 and 240 min (p&lt;0.05 for both).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Myocardial protection for two hours of polarizing cardioplegic arrest with STH-POL in oxygenated blood is non-inferior compared to STH-2 blood cardioplegia. STH-POL cardioplegia alleviates the mismatch between myocardial function and perfusion after weaning from CPB<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0267659118791357","type":"journal-article","created":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T10:35:51Z","timestamp":1532946951000},"page":"67-75","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Left ventricular dysfunction after two hours of polarizing or depolarizing cardioplegic arrest in a porcine model"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4207-3454","authenticated-orcid":false,"given":"Terje","family":"Aass","sequence":"first","affiliation":[{"name":"Section of Cardiothoracic Surgery, Department of Heart Disease, Haukeland University Hospital, Bergen, Norway"},{"name":"Department of Clinical Science, Faculty of Medicine, University of Bergen, Bergen, 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Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Chambers","sequence":"additional","affiliation":[{"name":"Cardiac Surgical Research, The Rayne Institute (King\u2019s College London), Guy\u2019s and St Thomas\u2019 NHS Foundation Trust, St Thomas\u2019 Hospital, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malte","family":"Urban","sequence":"additional","affiliation":[{"name":"Section of Cardiothoracic Surgery, Department of Heart Disease, Haukeland University Hospital, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Knut","family":"Nesheim","sequence":"additional","affiliation":[{"name":"Section of Cardiothoracic Surgery, Department of Heart Disease, Haukeland University Hospital, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rune","family":"Haaverstad","sequence":"additional","affiliation":[{"name":"Section of Cardiothoracic Surgery, 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