{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:28:36Z","timestamp":1777915716544,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2019,1,11]],"date-time":"2019-01-11T00:00:00Z","timestamp":1547164800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100003243","name":"ministerstvo zdravotnictv\u00ed cesk\u00e9 republiky","doi-asserted-by":"publisher","award":["MH CZ-DRO \u2013 VFN64165"],"award-info":[{"award-number":["MH CZ-DRO \u2013 VFN64165"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Charles University project","award":["Progres Q25"],"award-info":[{"award-number":["Progres Q25"]}]},{"name":"Charles University project","award":["SVV 260373"],"award-info":[{"award-number":["SVV 260373"]}]},{"DOI":"10.13039\/501100003061","name":"erasmus medisch centrum","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003061","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perfusion"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Sufentanil is a potent analgesic drug used for pain management. A few studies describe the pharmacokinetics of sufentanil in neonates; however, no pharmacokinetic data about sufentanil during extracorporeal membrane oxygenation have been published yet.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case report:<\/jats:title>\n                    <jats:p>A 1-day-old neonate with moderate hypoxic\u2013ischemic encephalopathy received veno-arterial extracorporeal membrane oxygenation support for refractory respiratory and circulatory failure. Sufentanil plasma concentrations were determined during both extracorporeal membrane oxygenation (n\u2009=\u200914) and non\u2013extracorporeal membrane oxygenation (n\u2009=\u200917) period. Based on these measurements, individual sufentanil pharmacokinetic parameters were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>We observed increased sufentanil volume of distribution (11.6 vs 5.6\u2009L\/kg) and decreased sufentanil clearance (0.535 vs 0.746\u2009L\/h\/kg) in extracorporeal membrane oxygenation period. The increment of volume of distribution was attributed to ECMO influence, while difference in clearance was probably due to drug interaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This is the first description of sufentanil pharmacokinetics in neonate treated with extracorporeal membrane oxygenation. We observed considerably larger volume of distribution during extracorporeal membrane oxygenation period in comparison with non\u2013extracorporeal membrane oxygenation period.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0267659118824011","type":"journal-article","created":{"date-parts":[[2019,1,11]],"date-time":"2019-01-11T09:46:07Z","timestamp":1547199967000},"page":"433-436","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Sufentanil pharmacokinetics in a full-term neonate treated with extracorporeal membrane oxygenation: a case report"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6803-7350","authenticated-orcid":false,"given":"Pavla","family":"Pokorn\u00e1","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine (PICU\/NICU), First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic"},{"name":"Institute of Pharmacology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic"},{"name":"Intensive Care and Department of Pediatric Surgery, Erasmus Medical Center\u2013Sophia Children\u2019s Hospital, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6541-738X","authenticated-orcid":false,"given":"Martin","family":"\u0160\u00edma","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00e1clav","family":"Vobruba","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine (PICU\/NICU), First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Ba\u0161kov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine (PICU\/NICU), First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lenka","family":"Posch","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine (PICU\/NICU), First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic"},{"name":"Institute of Pharmacology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ond\u0159ej","family":"Slana\u0159","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology, First Faculty 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