{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T08:19:10Z","timestamp":1790151550943,"version":"4.0.1"},"reference-count":47,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T00:00:00Z","timestamp":1561507200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000871","name":"mayo clinic","doi-asserted-by":"publisher","award":["RDCRKAD1"],"award-info":[{"award-number":["RDCRKAD1"]}],"id":[{"id":"10.13039\/100000871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NeuroSave Inc"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perfusion"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background\/objective:<\/jats:title>\n                    <jats:p>Reduction of brain temperature remains the most common method of neuroprotection against ischemic injury employed during cardiac surgery. However, cooling delivered via the cardiopulmonary bypass circuit is brief and cooling the body core along with the brain has been associated with a variety of unwanted effects. This study investigated the feasibility and safety of a novel selective brain cooling approach to induce rapid, brain-targeted hypothermia independent of the cardiopulmonary bypass circuit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This first-in-human feasibility study enrolled five adults undergoing aortic valve replacement with cardiopulmonary bypass support. During surgery, the NeuroSave system circulated chilled saline within the pharynx and upper esophagus. Brain and body core temperature were continuously monitored. Adverse effects, cardiopulmonary function, and device function were noted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Patient 1 received cooling fluid for an insignificant period, and Patients 2-5 successfully underwent the cooling procedure using the NeuroSave system for 56-89\u2009minutes. Cooling fluid was 12\u00b0C for Patients 1-3, 6\u00b0C for Patient 4, and 2\u00b0C for Patient 5. There were no NeuroSave-related adverse events and no alterations in cardiopulmonary function during NeuroSave use. Brain temperature decreased by 3\u00b0C within 15\u2009minutes and remained at least 3.5\u00b0C colder than the body core. During a brief episode of hypotension in one patient, the brain cooled an additional 4\u00b0C in 2\u2009minutes, briefly reaching 27.4\u00b0C.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The NeuroSave system can induce rapid brain-targeted hypothermia and simultaneously maintain a favorable body\u2013brain temperature gradient, even during hypotension. Further studies are required to evaluate the function of the system during longer periods of use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0267659119853950","type":"journal-article","created":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T03:22:02Z","timestamp":1561519322000},"page":"96-103","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Selective brain hypothermia: feasibility and safety study of a novel method in five patients"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8219-6144","authenticated-orcid":false,"given":"Seyed Mohammad","family":"Seyedsaadat","sequence":"first","affiliation":[{"name":"Department of Radiology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana F","family":"Marasco","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, The 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