{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:28:54Z","timestamp":1777915734038,"version":"3.51.4"},"reference-count":8,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T00:00:00Z","timestamp":1565136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perfusion"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>New antibiotics with bactericidal activity against multi-drug-resistant bacteria are increasingly used in the intensive care units. Here, we aimed to evaluate the influence of the extracorporeal membrane oxygenation on plasma levels of ceftolozane.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case report:<\/jats:title>\n                    <jats:p>A 34-year-old female was admitted to the intensive care unit after bilateral lung transplantation, complicated by primary graft dysfunction and cardiogenic shock needing venoarterial extracorporeal membrane oxygenation. Ceftolozane\/tazobactam was started. Plasma ceftolozane levels were monitored on the first and third days of antibiotic treatment. A non-compartment pharmacokinetic analysis was performed and the extraction rate through the oxygenator was calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>The extracorporeal circuit of extracorporeal membrane oxygenation may alter the pharmacokinetics of antibiotics, to varying degrees due to drug sequestration and increased distribution volume. In this case, the extracorporeal membrane oxygenation circuit had little impact on the ceftolozane plasma concentration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Plasma levels of ceftolozane are stable in the extracorporeal membrane oxygenation circuit, suggesting that adjustment of standard doses of ceftolozane in patients with extracorporeal membrane oxygenation support may not be needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0267659119864813","type":"journal-article","created":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T03:22:45Z","timestamp":1565148165000},"page":"267-270","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Effects of the extracorporeal membrane oxygenation circuit on plasma levels of ceftolozane"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4564-2421","authenticated-orcid":false,"given":"Eduard","family":"Argudo","sequence":"first","affiliation":[{"name":"Intensive Care Medicine Department, Vall d\u2019Hebron University Hospital, Barcelona, Spain"},{"name":"Sepsis, Organ Dysfunction and Resuscitation (SODIR) Research Group, Vall d\u2019Hebron Research Institute, Barcelona, Spain"},{"name":"Department of Medicine, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordi","family":"Riera","sequence":"additional","affiliation":[{"name":"Intensive Care Medicine Department, Vall d\u2019Hebron University Hospital, Barcelona, Spain"},{"name":"Sepsis, Organ Dysfunction and Resuscitation (SODIR) Research Group, Vall d\u2019Hebron Research Institute, Barcelona, Spain"},{"name":"Department of Medicine, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red, Enfermedades Respiratorias (CIBERES), Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Luque","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Hospital del Mar, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8835-2702","authenticated-orcid":false,"given":"Ibai","family":"Los-Arcos","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Vall d\u2019Hebron University Hospital, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"L\u00f3pez-Meseguer","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red, Enfermedades Respiratorias (CIBERES), Madrid, Spain"},{"name":"Pneumology Department, Vall d\u2019Hebron University Hospital, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Sandiumenge","sequence":"additional","affiliation":[{"name":"Medical Transplant Coordination Department, Vall d\u2019Hebron University Hospital, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Nuvials","sequence":"additional","affiliation":[{"name":"Intensive Care Medicine Department, Vall d\u2019Hebron University Hospital, Barcelona, Spain"},{"name":"Sepsis, Organ Dysfunction and Resuscitation (SODIR) Research Group, Vall d\u2019Hebron Research Institute, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santiago","family":"Grau","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Hospital del Mar, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricard","family":"Ferrer","sequence":"additional","affiliation":[{"name":"Intensive Care Medicine Department, Vall d\u2019Hebron University Hospital, Barcelona, Spain"},{"name":"Sepsis, Organ Dysfunction and Resuscitation (SODIR) Research Group, Vall d\u2019Hebron Research Institute, Barcelona, Spain"},{"name":"Department of Medicine, Universitat Aut\u00f2noma de Barcelona, Barcelona, 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