{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:29:55Z","timestamp":1777915795515,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T00:00:00Z","timestamp":1605484800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perfusion"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Extracorporeal Membrane Oxygenation (ECMO) is a temporary therapy option for refractory cardiac or respiratory failure. Preliminary study suggests that ECMO aids in the recovery of end-organ function by maintaining systemic perfusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A retrospective IRB approved database research and chart review was performed on patients initiated on veno-arterial (VA-) ECMO between September 2010 and April 2019. End-organ injury markers were compared between the pre-ECMO period, defined as markers recorded before ECMO initiation, and the pre-decannulation period, defined as markers prior to ECMO decannulation. Data was expressed with mean\u2009\u00b1\u2009standard deviation, or median [quartile 1, quartile 3] and compared between Pre-ECMO and per-decannulation period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Among the 159 VA-ECMO patients, 100 patients (63%) survived ECMO with mean ECMO duration 10\u2009\u00b1\u20097\u2009days. Within the survival group, 78 patients (49%) weaned to recovery, and 22 patients (14%) weaned off to durable implantable devices. Compared to the pre-ECMO period, the pre-decannulation period significantly improved in pH (7.23\u2009\u00b1\u20090.19 vs. 7.40\u2009\u00b1\u20090.09; p\u2009&lt;\u20090.001) and lactate (5.5 [2.3, 9.0] vs. 1.6 [0.9, 2.3]; p\u2009&lt;\u20090.001), and serum creatinine (1.4 [1.1, 2.1] vs. 1.1 [0.8, 1.7]; p\u2009&lt;\u20090.001). Significant changes were noted in ventilation parameters as well, such as FiO\n                      <jats:sub>2<\/jats:sub>\n                      (100 [100, 100] vs. 50 [50, 50]; p\u2009&lt;\u20090.001), PaO\n                      <jats:sub>2<\/jats:sub>\n                      (88 [62, 135], 126 [87, 162]; p\u2009&lt;\u20090.001) and PEEP (8.0 [5.0, 12.0] vs. 5.0 [5.0, 8.0]; p\u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Maintaining perfusion with VA-ECMO utilization on indicated patients demonstrated improvements in end-organ functions. Survival rates of VA-ECMO patients were also optimistic.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0267659120969288","type":"journal-article","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T00:44:06Z","timestamp":1605573846000},"page":"808-813","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes of end-organ function and survival with veno-arterial extracorporeal membrane oxygenation"],"prefix":"10.1177","volume":"36","author":[{"given":"Toru","family":"Mihama","sequence":"first","affiliation":[{"name":"Department of Surgery, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nataliya","family":"Bahatyrevich","sequence":"additional","affiliation":[{"name":"Department of Surgery, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Cavarocchi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5210-810X","authenticated-orcid":false,"given":"Hitoshi","family":"Hirose","sequence":"additional","affiliation":[{"name":"Department of Surgery, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,11,16]]},"reference":[{"key":"bibr1-0267659120969288","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.12690"},{"key":"bibr2-0267659120969288","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.12058"},{"key":"bibr3-0267659120969288","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2015.04.044"},{"key":"bibr4-0267659120969288","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8122218"},{"key":"bibr5-0267659120969288","doi-asserted-by":"publisher","DOI":"10.4236\/wjcs.2012.24015"},{"key":"bibr6-0267659120969288","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e3181b806fc"},{"key":"bibr7-0267659120969288","unstructured":"Extracorporeal Life Support Organization (ELSO). ECLS registry report international summary, https:\/\/www.elso.org\/Registry\/Statistics.aspx (accessed 20 May 2020)."},{"key":"bibr8-0267659120969288","doi-asserted-by":"publisher","DOI":"10.1186\/cc2872"},{"key":"bibr9-0267659120969288","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2017.06.007"},{"key":"bibr10-0267659120969288","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000824"}],"container-title":["Perfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0267659120969288","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0267659120969288","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0267659120969288","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T17:29:55Z","timestamp":1777656595000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0267659120969288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,16]]},"references-count":10,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1177\/0267659120969288"],"URL":"https:\/\/doi.org\/10.1177\/0267659120969288","relation":{},"ISSN":["0267-6591","1477-111X"],"issn-type":[{"value":"0267-6591","type":"print"},{"value":"1477-111X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,16]]}}}