{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:29:57Z","timestamp":1777915797300,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T00:00:00Z","timestamp":1607558400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Beijing Lisheng Cardiovascular Health Foundation","award":["LHJJ20159523"],"award-info":[{"award-number":["LHJJ20159523"]}]},{"name":"Medical and Health Science and Technology Development Projects of Shandong","award":["2015WS0218"],"award-info":[{"award-number":["2015WS0218"]}]},{"DOI":"10.13039\/501100007129","name":"natural science foundation of shandong province","doi-asserted-by":"publisher","award":["ZR2015HL003"],"award-info":[{"award-number":["ZR2015HL003"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770334"],"award-info":[{"award-number":["81770334"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Innovation Program for Clinical Medicine of Jinan","award":["201602176"],"award-info":[{"award-number":["201602176"]}]},{"name":"Taishan Scholar Engineering Construction Fund of Shandong Province","award":["ts201511104"],"award-info":[{"award-number":["ts201511104"]}]},{"DOI":"10.13039\/501100015507","name":"shandong first medical university","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015507","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perfusion"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To evaluate the effect of individualized antiplatelet therapy, based on CYP2C19 genotyping, on platelet function in patients underwent PCI and to compare this treatment with conventional antiplatelet therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      All patients were treated with 100\u2009mg aspirin once a day. Additionally, the CA group received 75\u2009mg clopidogrel once a day. The IA group was divided into extensive metabolizers (EMs, no loss-of-function, i.e. LOF allele, 75\u2009mg clopidogrel once a day), intermediate metabolizers (IMs, carrying one LOF alleles, 75\u2009mg clopidogrel twice daily), and poor metabolizers group (PMs, carrying two LOF alleles, 90\u2009mg ticagrelor twice daily). After taking these antiplatelet medications for \u2a7e5\u2009days, we assessed platelet function by thromboelastography, and recorded the MA\n                      <jats:sub>ADP<\/jats:sub>\n                      (maximum amplitude produced by adenosine diphosphate) value. MA\n                      <jats:sub>ADP<\/jats:sub>\n                      \u2009&gt;\u200947\u2009mm was defined as residual HPR, indicating a high risk of thrombosis. MA\n                      <jats:sub>ADP<\/jats:sub>\n                      \u2009\u2264\u200931\u2009mm indicated a high risk of bleeding.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The proportion of patients with MA\n                      <jats:sub>ADP<\/jats:sub>\n                      \u2009&gt;\u200947\u2009mm was significantly lower in the IA group (29.6%) than the CA group (38.1%). The proportion of patients with MA\n                      <jats:sub>ADP<\/jats:sub>\n                      \u2009\u2264\u200931\u2009mm was significantly higher in the IA group (31.0%) than the CA group (21.3%). No significant differences were found in the proportions of patients with MA\n                      <jats:sub>ADP<\/jats:sub>\n                      \u2009&gt;\u200947\u2009mm or MA\n                      <jats:sub>ADP<\/jats:sub>\n                      \u2009\u226431\u2009mm when compared between the EMs and IMs group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Individualized antiplatelet therapy, based on CYP2C19 genotyping, can reduce the incidence of HPR in ACS patients after PCI compared to conventional therapy. By taking a double dose of clopidogrel, patients with a CYP2C19 LOF allele can therefore overcome the reduced efficacy of clopidogrel associated with LOF alleles without increasing the risk of bleeding, which is of guiding significance for the management of antiplatelet therapy on ACS patients after PCI especially considering the CYP2C19 LOF alleles that carry an important predictor for the ischemic events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration number:<\/jats:title>\n                    <jats:p>chiCTR-INC-17011550.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0267659120978584","type":"journal-article","created":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T14:05:02Z","timestamp":1607609102000},"page":"78-85","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Effects of individualized antiplatelet therapy, based on CYP2C19 genotyping, on platelet function in patients underwent percutaneous coronary intervention"],"prefix":"10.1177","volume":"37","author":[{"given":"Min","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China"},{"name":"Department of Cardiology, the Fifth People\u2019s Hospital of Jinan, Jinan, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangrong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangyang","family":"Chao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4711-3865","authenticated-orcid":false,"given":"Mei","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinglong","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,12,10]]},"reference":[{"key":"bibr1-0267659120978584","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra071014"},{"key":"bibr2-0267659120978584","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2008.01.005"},{"key":"bibr3-0267659120978584","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv320"},{"key":"bibr4-0267659120978584","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx393"},{"key":"bibr5-0267659120978584","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.09.017"},{"key":"bibr6-0267659120978584","first-page":"380","volume":"43","author":"China Society of Cardiology of Chinese Medical Association, Editorial Board of Chinese Journal of Cardiology, China Society of Cardiology of Chinese Medical Association Editorial Board of Chinese Journal of Cardiology","year":"2015","journal-title":"Zhonghua Xin Xue Guan Bing Za 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