{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T19:49:37Z","timestamp":1782762577225,"version":"3.54.5"},"reference-count":6,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,2,26]],"date-time":"2022-02-26T00:00:00Z","timestamp":1645833600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perfusion"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Propofol infusion syndrome (PRIS) is a rare entity that could lead to profound cardiogenic shock (CS). Mitochondrial toxicity and sympathetic blockade are the mechanisms leading to CS in PRIS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case report<\/jats:title>\n                    <jats:p>\n                      We present a 22-year-old woman who developed refractory CS due to PRIS after aortic valve replacement surgery secondary to\n                      <jats:italic toggle=\"yes\">Coxiella<\/jats:italic>\n                      infective endocarditis. She was rescued with VA-ECMO (veno-arterial extracorporeal membrane oxygenation) and was discharged 2\u00a0months later with no cardiac dysfunction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>PRIS diagnosis is difficult even though propofol is frequently used in critical care units. Abrupt refractory CS in patients with recent use of high doses of propofol (&gt; 4\u00a0mg\/Kg\/h) together with rhabdomyolysis should raise the suspicion. Diagnostic confirmation is based on muscle biopsy and fat enzyme analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Propofol withdrawal and support therapies\u2014including VA-ECMO\u2014are the treatment of choice in severe PRIS. VA-ECMO could increase survival as a bridge to recovery due to reversibility of PRIS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02676591221078143","type":"journal-article","created":{"date-parts":[[2022,2,26]],"date-time":"2022-02-26T09:35:21Z","timestamp":1645868121000},"page":"868-871","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["VA-ECMO rescue therapy in propofol infusion syndrome after cardiac surgery"],"prefix":"10.1177","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3937-9639","authenticated-orcid":false,"given":"Mar\u00eda Plaza","family":"Mart\u00edn","sequence":"first","affiliation":[{"name":"Hospital Cl\u00ednico Universitario de Valladolid"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma Pastor","family":"B\u00e1ez","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario de Valladolid"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo Garc\u00eda","family":"Cabello","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario de Valladolid"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Stepanenko","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario de Valladolid"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Alberto","family":"San Rom\u00e1n Calvar","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario de Valladolid"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aitor Uribarri","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario de Valladolid"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,2,26]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2018.12.025"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/260385"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2018.12.019"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2007.05055.x"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001503-200206000-00010"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-020-06280-3"}],"container-title":["Perfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02676591221078143","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/02676591221078143","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02676591221078143","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T19:33:42Z","timestamp":1782761622000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/02676591221078143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,26]]},"references-count":6,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1177\/02676591221078143"],"URL":"https:\/\/doi.org\/10.1177\/02676591221078143","relation":{},"ISSN":["0267-6591","1477-111X"],"issn-type":[{"value":"0267-6591","type":"print"},{"value":"1477-111X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,26]]}}}