{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T19:49:42Z","timestamp":1782762582499,"version":"3.54.5"},"reference-count":30,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T00:00:00Z","timestamp":1649030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perfusion"],"published-print":{"date-parts":[[2023,5]]},"abstract":"\n Background<\/jats:title>\n \n Thrombocytopenia (platelet count below 150 x 10\n 3<\/jats:sup>\n \/\u03bcL) is a common finding after open-heart surgery and can lead to various complications, including patient death. This study aimed to determine the extent of non\u2013heparin-induced thrombocytopenia in open-heart surgery and to highlight the associated factors.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n \n In this cohort study, 842 patients who underwent valve and\/or coronary bypass surgery over a 5-year period were retrospectively analyzed. After open-heart surgery, patients whose platelet count was less than 150 x 10\n 3<\/jats:sup>\n \/\u03bcL on a complete blood count 12 and 24\u00a0h after surgery were classified as thrombocytopenic. Three hundred twenty patients without thrombocytopenia and 21 patients with a high probability of heparin-induced thrombocytopenia were excluded from the study. Logistic regression analysis was used to assess the association of independent variables in moderate-severe thrombocytopenia: Age groups, sex, underlying disease, symptoms, type of surgery, pump time, pulsatile or non-pulsatile duration, degree of hypothermia, hemodilution, oxygenator type, use of an intra-aortic balloon, and erythrocyte transfusion counts were included in the analysis.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 501 patients were diagnosed as having non\u2013heparin-induced thrombocytopenia, and 64.3% were male. Three hundred seventy-seven (75.2%) patients had mild thrombocytopenia and 124 (24.7%) had moderate-severe thrombocytopenia. The postoperative platelet count was significantly lower than the preoperative platelet count (213 x 10\n 3<\/jats:sup>\n vs.117 x 10\n 3<\/jats:sup>\n \/\u03bcL;\n p<\/jats:italic>\n < 0.001). Moderate-severe thrombocytopenia was associated with age \u226580\u00a0years odds (OR = 9.026, 95% CI: [1.757\u201346.363];\n p<\/jats:italic>\n = 0.008), isolated valve surgery (OR = 3.090, 95% CI: [1.867\u20135.114];\n p<\/jats:italic>\n < 0.001), and valve surgery with coronary bypass (OR = 4.938, 95% CI: [1.638\u201314.889];\n p<\/jats:italic>\n = 0.005) compared to isolated coronary bypass, type of oxygenator (Nipro vital compared with Affinity OR = 11.097, 95% CI: [1.923\u201364.023];\n p<\/jats:italic>\n = 0.007), erythrocyte transfusion count (OR = 1.219, 95%CI: [1.046\u20131.420];\n p<\/jats:italic>\n = 0.011).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Age 80\u00a0years or older, surgical procedures including heart-valve surgery, and the number of red blood cell transfusions are associated with the risk of moderate-to-severe thrombocytopenia. This study provides a guide in terms of risk factors that may lead to moderate-to-severe thrombocytopenia after open-heart surgery. However, future multicentre prospective randomized studies may provide more detailed information on this subject.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/02676591221082496","type":"journal-article","created":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T08:53:28Z","timestamp":1649062408000},"page":"781-790","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Non-heparin-induced thrombocytopenia in patients after open-heart surgery"],"prefix":"10.1177","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8866-3719","authenticated-orcid":false,"given":"Ercan","family":"Keles","sequence":"first","affiliation":[{"name":"Bak\u0131rcay University Cigli Training and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cagatay","family":"Bilen","sequence":"additional","affiliation":[{"name":"Health Sciences University Dr Behcet Uz Training and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakan","family":"Aygun","sequence":"additional","affiliation":[{"name":"Bak\u0131rcay University Cigli Training and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tugra","family":"Gencpinar","sequence":"additional","affiliation":[{"name":"Dokuz Eyl\u00fcl University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hudai","family":"Catalyurek","sequence":"additional","affiliation":[{"name":"Dokuz Eyl\u00fcl University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,4,4]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1092871"},{"issue":"3","key":"e_1_3_3_3_2","first-page":"915","article-title":"Efficient diagnosis of thrombocytopenia","volume":"53","author":"Goldstein KH","year":"1996","unstructured":"Goldstein KH, Abramson N. 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