{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:33:44Z","timestamp":1788395624270,"version":"build-2803163510"},"reference-count":28,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T00:00:00Z","timestamp":1661731200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perfusion"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) flows are titrated to achieve adequate perfusion while attempting to ideally maintain arterial pulse pressure (PP). We assessed risk in patients with low PP defined as &lt;10\u00a0mmHg within the first 2\u00a0days of support.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Demographics, haemodynamics, echocardiographic and radiological findings were recorded retrospectively in cases conducted between 2014 and 2016. Outcomes were hospital mortality, requirement for renal replacement therapy (RRT) and severe pulmonary oedema (PO).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 101 patients, 66.3% were male, mean age was 56 (range 18\u201371\u00a0years), mean duration of support was 6.3 days \u00b1 4.1\u00a0days, 37.6% died prior to hospital discharge, 39.6% needed RRT and 11.9% had severe PO. Areas under the receiver operating curves of PP at 48\u00a0h for hospital mortality, RRT and severe PO were (respectively): 0.69 (95% CI 0.58\u20130.80, p = .001), 0.64 (95% CI 0.50\u20130.77, p = .044), 0.69 (95% CI 0.55\u20130.82, p = .009). The odds ratio for mortality, RRT, severe PO for those with low PP were (respectively) 2.8 (95% CI 1.01\u20137.5, p = .04), 3.1 (95% CI 1.11\u20138.40, p = .026), 7.6 (95% CI 2.06\u201327.89, p = .001). Central venous pressure, mean arterial pressure were not predictive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PP during the first 2\u00a0days of support is predictive of clinically important outcomes in patients supported with VA-ECMO.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02676591221115935","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T09:15:26Z","timestamp":1661764526000},"page":"1568-1576","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Pulse pressure within the first 2 days of veno-arterial extracorporeal membrane oxygenation is predictive of death prior to hospital discharge, renal dysfunction requiring dialysis and pulmonary oedema"],"prefix":"10.1177","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9498-5573","authenticated-orcid":false,"given":"Maithri","family":"Siriwardena","sequence":"first","affiliation":[{"name":"Department of Intensive Care, St Vincent\u2019s Hospital, Sydney, Darlinghurst, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff","family":"Breeding","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, St Vincent\u2019s Hospital, Sydney, Darlinghurst, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mani","family":"Gopalakrishnan","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, St Vincent\u2019s Hospital, Sydney, Darlinghurst, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Jansz","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, St Vincent\u2019s Hospital, Sydney, Darlinghurst, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily K","family":"Granger","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, St Vincent\u2019s Hospital, Sydney, Darlinghurst, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Jackson","sequence":"additional","affiliation":[{"name":"Department of Cardiac Anaesthesia, St Vincent\u2019s Hospital, Sydney, Darlinghurst, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter S","family":"MacDonald","sequence":"additional","affiliation":[{"name":"Cardiac Failure and Transplantation, St Vincent\u2019s Hospital, Sydney, Darlinghurst, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Lowe","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, St Vincent\u2019s Hospital, Sydney, Darlinghurst, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hergen","family":"Buscher","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, St Vincent\u2019s Hospital, Sydney, Darlinghurst, NSW, Australia"},{"name":"University of New South Wales, Sydney, NSW, Australia"},{"name":"Centre of Applied Medical Research, St Vincent\u2019s Hospital, Sydney, Darlinghurst, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priya","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, St Vincent\u2019s Hospital, Sydney, Darlinghurst, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,8,29]]},"reference":[{"key":"bibr1-02676591221115935","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs081"},{"key":"bibr2-02676591221115935","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/393258"},{"key":"bibr3-02676591221115935","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-011-2358-2"},{"key":"bibr4-02676591221115935","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/175768"},{"key":"bibr5-02676591221115935","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2009.10.043"},{"key":"bibr6-02676591221115935","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2016.10.023"},{"key":"bibr7-02676591221115935","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv194"},{"key":"bibr8-02676591221115935","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-016-4657-0"},{"key":"bibr9-02676591221115935","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2012.02.009"},{"key":"bibr10-02676591221115935","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2003.12.011"},{"key":"bibr11-02676591221115935","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000000153"},{"key":"bibr12-02676591221115935","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041290"},{"key":"bibr13-02676591221115935","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000392"},{"key":"bibr14-02676591221115935","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-015-0634-6"},{"key":"bibr15-02676591221115935","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2017.09.004"},{"key":"bibr16-02676591221115935","doi-asserted-by":"publisher","DOI":"10.1177\/0267659118787426"},{"key":"bibr17-02676591221115935","unstructured":"Brogan TV, Lequier L, Lorusso R, et al. Extracorporeal life support: the ELSO red book. Ann Arbor, MI: Extracorporeal Life Support Organization."},{"key":"bibr18-02676591221115935","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.09.124"},{"key":"bibr19-02676591221115935","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2013.04.009"},{"key":"bibr20-02676591221115935","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-021-01838-7"},{"key":"bibr21-02676591221115935","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2013.09.008"},{"key":"bibr22-02676591221115935","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs398"},{"key":"bibr23-02676591221115935","doi-asserted-by":"publisher","DOI":"10.1177\/039139880803100210"},{"key":"bibr24-02676591221115935","doi-asserted-by":"publisher","DOI":"10.1177\/2048872617711169"},{"issue":"10","key":"bibr25-02676591221115935","first-page":"453","volume":"27","author":"Cheng R","year":"2015","journal-title":"J Invasive Cardiol"},{"key":"bibr26-02676591221115935","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.048792"},{"key":"bibr27-02676591221115935","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2016.07.019"},{"key":"bibr28-02676591221115935","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000001024"}],"container-title":["Perfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02676591221115935","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/02676591221115935","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02676591221115935","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T17:32:06Z","timestamp":1777656726000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/02676591221115935"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,29]]},"references-count":28,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1177\/02676591221115935"],"URL":"https:\/\/doi.org\/10.1177\/02676591221115935","relation":{},"ISSN":["0267-6591","1477-111X"],"issn-type":[{"value":"0267-6591","type":"print"},{"value":"1477-111X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,29]]}}}