{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:05:47Z","timestamp":1787018747481,"version":"build-2736575974"},"reference-count":32,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T00:00:00Z","timestamp":1659916800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Haiyang Li","award":["82070483"],"award-info":[{"award-number":["82070483"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perfusion"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To analyze the effect of sex on the short-time prognosis in two different age subgroups (\u226455\u00a0years old and &gt;55\u00a0years old).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From January 2009 to 2019, 1522 patients with DeBakey I acute aortic dissection (AAD) underwent frozen elephant trunk and total arch replacement at a Tertiary Center in China were divided into female group ( n = 324) and male group ( n = 1198). The demographic characteristics, clinical presentation, management, short-term outcomes were described in the different sex groups. The risk factors of 30-days mortality for females and males were identified by univariate and multivariable logistic regression analysis. Then, random Forest regression was used to analyze the association between age and 30-days mortality in the different sexes groups. The cut-off age for 30-days mortality in females was then identified as 55\u00a0years. The patients were divided into two subgroups: young patients (\u226455\u00a0years old) and elderly patients (&gt;55\u00a0years old). Clinical prognosis between different sex groups was further compared in the age subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Approximately four-fifths of the patients were males. Males with DeBakey I AAD were younger than females (47 vs 52\u00a0years; p &lt; 0.01). The proportion of males gradually declined with age. The cut-off age for 30-days mortality in females and males was identified as 55\u00a0years old and 63\u00a0years old, respectively. In young patients (\u226455\u00a0years old), the 30-days mortality rate for females was lower than males (hazard ratio [HR, 2.02, p &lt; 0.05). Following adjustment using the multivariable Cox regression analysis, females were identified as an independent protective factor for 30-days mortality (HR, 2.24, p = 0.03).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study showed that females present with DeBakey I AAD less frequently than males and they tend to present with DeBakey AAD later in life. In young patients, females had better early outcomes despite similar time for symptom onset to diagnosis and surgical technique than males.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02676591221118322","type":"journal-article","created":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T23:56:52Z","timestamp":1660003012000},"page":"1478-1491","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Differences between sexes in patients who underwent total arch replacement and frozen elephant trunk procedures for acute dissection"],"prefix":"10.1177","volume":"38","author":[{"given":"Zeling","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of 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