{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:03:18Z","timestamp":1791583398436,"version":"4.3.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T00:00:00Z","timestamp":1664323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perfusion"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Introduction: Comprehensive genetic testing with whole-exome (WES) or whole-genome (WGS) sequencing facilitates diagnosis, can optimize treatment, and may improve outcomes in critically ill neonates, including those requiring extracorporeal membrane oxygenation (ECMO) for respiratory failure. Our objective was to describe practice variation and barriers to the utilization of comprehensive genetic testing for neonates on ECMO.<\/jats:p>\n                  <jats:p>Methods: We performed a cross-sectional survey of Level IV neonatal intensive care units in the United States across the Children\u2019s Hospitals Neonatal Consortium (CHNC).<\/jats:p>\n                  <jats:p>Results: Common indications for WES and WGS included concerning phenotype, severity of disease, unexpected postnatal clinical course, and inability to wean from ECMO support. Unexpected severity of disease on ECMO was the most common indication for rapid genetic testing. Cost of utilization was the primary barrier to testing. If rapid WES or WGS were readily available, 63% of centers would consider incorporating universal screening for neonates upon ECMO cannulation.<\/jats:p>\n                  <jats:p>Conclusion: Despite variation in the use of WES and WGS, universal testing may offer earlier diagnosis and influence the treatment course among neonates on ECMO. Cost is the primary barrier to utilization and most centers would consider incorporating universal screening on ECMO if readily available.<\/jats:p>","DOI":"10.1177\/02676591221130178","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T10:19:53Z","timestamp":1664360393000},"page":"116-123","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Current Practices for Genetic Testing in Neonatal Extracorporeal Membrane Oxygenation: Findings from a National survey"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0016-078X","authenticated-orcid":false,"given":"K. Taylor","family":"Wild","sequence":"first","affiliation":[{"name":"Children\u2019s Hospital of Philadelphia, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franscesca","family":"Miquel-Verges","sequence":"additional","affiliation":[{"name":"Arkansas Children\u2019s Hospital, University of Arkansas for Medical Sciences, Little Rock, AR, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie E","family":"Rintoul","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital of Philadelphia, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"DiGeronimo","sequence":"additional","affiliation":[{"name":"Seattle Children\u2019s Hospital, University of Washington, Seattle WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Keene","sequence":"additional","affiliation":[{"name":"Children\u2019s Healthcare of Atlanta, School of Medicine, Emory University, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon E","family":"Hamrick","sequence":"additional","affiliation":[{"name":"Children\u2019s Healthcare of Atlanta, School of Medicine, Emory University, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burhan","family":"Mahmood","sequence":"additional","affiliation":[{"name":"UPMC Children\u2019s Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8250-1858","authenticated-orcid":false,"given":"Rakesh","family":"Rao","sequence":"additional","affiliation":[{"name":"St. Louis Children\u2019s Hospital, Washington University School of Medicine, St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2488-2568","authenticated-orcid":false,"given":"Nicholas R","family":"Carr","sequence":"additional","affiliation":[{"name":"Primary Children\u2019s Hospital, University of Utah School of Medicine, Salt Lake City, UT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Children\u2019s Hospitals Neonatal Consortium (CHNC)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,9,28]]},"reference":[{"key":"bibr1-02676591221130178","volume-title":"Extracorporal life support organization (ELSO) ECLS registry report: international summary, January 2020","year":"2020"},{"key":"bibr2-02676591221130178","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0b013e3182904a52"},{"key":"bibr3-02676591221130178","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000001236"},{"key":"bibr4-02676591221130178","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2013.11.002"},{"key":"bibr5-02676591221130178","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000001153"},{"key":"bibr6-02676591221130178","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2013.11.009"},{"key":"bibr7-02676591221130178","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2003.010793"},{"key":"bibr8-02676591221130178","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2020.10.003"},{"key":"bibr9-02676591221130178","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2021.05.008"},{"key":"bibr10-02676591221130178","unstructured":"The NICUSeq Study Group, Krantz ID, Medne L, et al. Effect of whole-genome sequencing on the clinical management of acutely ill infants with suspected genetic disease: a randomized clinical trial.\n                      JAMA Pediatr\n                      . 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