{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:31:31Z","timestamp":1777915891123,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T00:00:00Z","timestamp":1665100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the Natural Sciences Foundation of Gansu","award":["20JR10RA760, 20JR10RA745, 20JR10RA733"],"award-info":[{"award-number":["20JR10RA760, 20JR10RA745, 20JR10RA733"]}]},{"name":"the Scientific Research Projects of Colleges in Gansu Province","award":["2020B-028, 2020B-049"],"award-info":[{"award-number":["2020B-028, 2020B-049"]}]},{"DOI":"10.13039\/100012899","name":"the Cuiying Scientific and Technological Innovation Program of Lanzhou University Second Hospital","doi-asserted-by":"publisher","award":["CY2019-QN01, CY2019-BJ07"],"award-info":[{"award-number":["CY2019-QN01, CY2019-BJ07"]}],"id":[{"id":"10.13039\/100012899","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Scientific Research Projects in Lanzhou","award":["2021-1-107"],"award-info":[{"award-number":["2021-1-107"]}]},{"name":"the Talent Introduction Plan of the Lanzhou University Second Hospital","award":["YJRCKYQDJ-2021-02"],"award-info":[{"award-number":["YJRCKYQDJ-2021-02"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perfusion"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Although venovenous extracorporeal membrane oxygenation (VV ECMO) is a reasonable salvage treatment for acute respiratory distress syndrome (ARDS), it requires sedating the patient. Sevoflurane and propofol have pulmonary protective and immunomodulatory properties. This study aimed to compare the effectiveness of sevoflurane and propofol on rats with induced ARDS undergoing VV ECMO.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Fifteen sprague-dawley (SD) rats were randomly divided into three groups: Con group, sevoflurane (Sevo) group and propofol (Pro) group. Arterial blood gas tests were performed at time pointsT0 (baseline), T1 (the time to ARDS), and T2 (weaning from ECMO). Oxygenation index (PaO\n                      <jats:sub>2<\/jats:sub>\n                      \/FiO\n                      <jats:sub>2<\/jats:sub>\n                      ) was calculated, and lung edema assessed by determining the lung wet:dry ratio. The protein concentration in bronchial alveolar lavage fluid (BALF) was determined by using bicinchoninic acid assay. Haematoxylin and eosin staining was used to evaluate the lung pathological scores in each group. IL-1\u03b2 and TNF-\u03b1 were also measured in the BALF, serum and lung.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Oxygenation index showed improvement in the Sevo group versus Pro group. The wet:dry ratio was reduced in the Sevo group compared with propofol-treated rats. Lung pathological scores were substantially lower in the Sevo group versus the Pro group. Protein concentrations in the BALF and levels of IL-1\u03b2 and TNF-\u03b1 in the Sevo group were substantially lower versus Pro group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrates that compared with propofol, sevoflurane was more efficacious in improving oxygenation and decreasing inflammatory response in rat models with ARDS subject to VV ECMO treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02676591221131217","type":"journal-article","created":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T12:29:19Z","timestamp":1665145759000},"page":"142-150","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Sevoflurane alleviates lung injury and inflammatory response compared with propofol in a rat model of VV ECMO"],"prefix":"10.1177","volume":"39","author":[{"given":"Rongzhi","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, Lanzhou University Second Hospital, Lanzhou, China"},{"name":"Department of Anesthesiology, Lanzhou University Second Hospital, Lanzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerong","family":"Zhai","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Lanzhou University Second Hospital, Lanzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Lanzhou University Second Hospital, Lanzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shilin","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Lanzhou University Second Hospital, Lanzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianbao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Lanzhou University Second Hospital, Lanzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanchun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Lanzhou University Second Hospital, Lanzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangyang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Lanzhou University Second Hospital, Lanzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0821-8875","authenticated-orcid":false,"given":"Yongnan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Lanzhou University Second Hospital, Lanzhou, China"},{"name":"Laboratory of 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