{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:31:34Z","timestamp":1777915894166,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T00:00:00Z","timestamp":1669248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perfusion"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Based on theoretical physiology, the ratio of pulmonary artery pulse pressure to mean pulmonary pressure (PP-MPAP), termed proportional pulmonary pulse pressure, provides a measure of coupling between the right ventricle and the pulmonary circulation. This study tested the hypothesis that lower PP-MPAP ratio was associated with left ventricular (LV) distension in patients with cardiogenic shock who underwent extracorporeal life support (ECLS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a retrospective observational single-centre study of 22 patients with cardiogenic shock who underwent ECLS as the primary support modality without and with LV distension and Impella unloading. The relationship between post-support PP-MPAP and 12-hour lactate clearance was also assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 22 patients: 10 patients underwent additional Impella unloading due to LV distension (Group 1) and 12 patients on ECLS only without LV distension (Group 2). As predicted by the theoretical model, PP-MPAP on ECLS dropped in Group 1 (pre-Impella) from 0.473 \u00b1 0.067 to 0.372 \u00b1 0.087, p &lt; 0.001; but increased in Group 2 patients without LV distension (0.518 \u00b1 0.070 to 0.549 \u00b1 0.072, p = 0.002). Impella support in Group 1 increased PP-MPAP (0.372 \u00b1 0.087 to 0.615 \u00b1 0.094, p &lt; 0.001). On multiple regression analysis, post-support PP-MPAP was significantly associated with 12-hour lactate clearance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Changes in PP-MPAP is associated hemodynamic response to ECLS and 12-hour lactate clearance. This simple parameter may guide therapeutic optimization in cardiogenic shock and ECLS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02676591221140744","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T12:21:59Z","timestamp":1669292519000},"page":"1034-1040","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Proportional pulmonary pulse pressure: A new index to assess response to veno-arterial extracorporeal membrane oxygenation"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6569-1805","authenticated-orcid":false,"given":"Hoong Sern","family":"Lim","sequence":"first","affiliation":[{"name":"Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,11,24]]},"reference":[{"key":"bibr1-02676591221140744","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.043080"},{"key":"bibr2-02676591221140744","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00336.2006"},{"key":"bibr3-02676591221140744","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00033.2013"},{"key":"bibr4-02676591221140744","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.051540"},{"key":"bibr5-02676591221140744","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000553"},{"key":"bibr6-02676591221140744","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000789"},{"key":"bibr7-02676591221140744","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2014.10.011"},{"key":"bibr8-02676591221140744","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.119.006486"},{"key":"bibr9-02676591221140744","doi-asserted-by":"publisher","DOI":"10.1378\/chest.108.5.1349"},{"key":"bibr10-02676591221140744","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0b013e3182a4b2f6"},{"key":"bibr11-02676591221140744","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.68.6.1495"},{"key":"bibr12-02676591221140744","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.25.6.637"},{"key":"bibr13-02676591221140744","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2006.04.036"},{"key":"bibr14-02676591221140744","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-015-4127-0"},{"key":"bibr15-02676591221140744","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.048792"}],"container-title":["Perfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02676591221140744","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/02676591221140744","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02676591221140744","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T17:32:32Z","timestamp":1777656752000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/02676591221140744"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,24]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1177\/02676591221140744"],"URL":"https:\/\/doi.org\/10.1177\/02676591221140744","relation":{},"ISSN":["0267-6591","1477-111X"],"issn-type":[{"value":"0267-6591","type":"print"},{"value":"1477-111X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,24]]}}}