{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T19:04:49Z","timestamp":1791572689211,"version":"4.3.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T00:00:00Z","timestamp":1673568000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"RegMed XB"},{"name":"EVICARE grant","award":["725229"],"award-info":[{"award-number":["725229"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perfusion"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>To validate slaughterhouse hearts for ex-situ heart perfusion studies, we compared cold oxygenated machine perfusion in less expensive porcine slaughterhouse hearts ( N = 7) to porcine hearts that are harvested following the golden standard in laboratory animals ( N = 6).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All hearts received modified St Thomas 2 crystalloid cardioplegia prior to 4\u00a0hours of cold oxygenated machine perfusion. Hearts were perfused with homemade modified Steen heart solution with a perfusion pressure of 20\u201325\u00a0mmHg to achieve a coronary flow between 100\u2013200\u00a0mL\/min. Reperfusion and testing was performed for 4 hours on a normothermic, oxygenated diluted whole blood loaded heart model. Survival was defined by a cardiac output above 3\u00a0L with a mean aortic pressure above 60\u00a0mmHg.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both groups showed 100% functional survival, with laboratory hearts displaying superior cardiac function. Both groups showed similar decline in function over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We conclude that the slaughterhouse heart can be used as an alternative to laboratory hearts and provides a cost-effective method for future ex-situ heart perfusion studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02676591231152718","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T12:56:21Z","timestamp":1673614581000},"page":"555-563","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Validation of the slaughterhouse porcine heart model for ex-situ heart perfusion studies"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7407-8703","authenticated-orcid":false,"given":"Selma E","family":"Kaffka genaamd Dengler","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mudit","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, University Medical Center Utrecht, Utrecht, The Netherlands"},{"name":"Laboratory of Experimental Cardiology, Department of Cardiology, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sjoerd","family":"van Tuijl","sequence":"additional","affiliation":[{"name":"LifeTec Group B.V., Kennedyplein 10-11, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskia CA","family":"de Jager","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Cardiology, Department of Cardiology, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost PG","family":"Sluijter","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Cardiology, Department of Cardiology, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter A","family":"Doevendans","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands"},{"name":"Netherlands Heart Institute, Moreelsepark 1, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels P","family":"van der Kaaij","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,1,13]]},"reference":[{"key":"bibr1-02676591231152718","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2020.10.001"},{"key":"bibr2-02676591231152718","doi-asserted-by":"publisher","DOI":"10.1007\/s12055-020-00998-x"},{"key":"bibr3-02676591231152718","doi-asserted-by":"publisher","DOI":"10.1038\/laban.1217"},{"key":"bibr4-02676591231152718","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-019-1242-9"},{"key":"bibr5-02676591231152718","doi-asserted-by":"publisher","DOI":"10.1016\/j.livsci.2017.03.021"},{"key":"bibr6-02676591231152718","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-016-0791-8"},{"key":"bibr7-02676591231152718","unstructured":"EU. 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