{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:46:14Z","timestamp":1787503574418,"version":"build-2736575974"},"reference-count":8,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T00:00:00Z","timestamp":1676505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perfusion"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:p>Introduction: Bioprosthetic mitral valve thrombosis (BPMVT) following post-operative extracorporeal membrane oxygenation (ECMO) is a rare complication with high mortality.<\/jats:p>\n                  <jats:p>Case Report: A 75-year-old man with a flail posterior mitral leaflet underwent a bioprosthetic mitral valve replacement and was subsequently placed on central veno-arterial high flow ECMO following intractable shock after protamine administration. He developed BPMVT over the following 48\u00a0hr, which did not resolve with 3\u00a0weeks of systemic heparin. He was then treated successfully with 3\u00a0days of continuous low dose (1\u00a0mg\/hr) Tissue Plasminogen Activator (TPA). He suffered no bleeding consequences and had a complete cardiac and end-organ recovery.<\/jats:p>\n                  <jats:p>Discussion: Slow TPA infusion may be an acceptable treatment strategy for alleviating thrombotic burden from a bioprosthetic valve, even in the post-operative setting.<\/jats:p>","DOI":"10.1177\/02676591231157200","type":"journal-article","created":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T16:38:21Z","timestamp":1676565501000},"page":"640-642","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Successful thrombolysis of early bioprosthetic mitral valve thrombosis following extracorporeal membrane oxygenation: Case report"],"prefix":"10.1177","volume":"39","author":[{"given":"Rosalind","family":"Groenewoud","sequence":"first","affiliation":[{"name":"Undergraduate Medical Education, University of British Columbia, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek","family":"Gunning","sequence":"additional","affiliation":[{"name":"Royal Columbian Hospital, New Westminster, BC, Canada"},{"name":"Division of Cardiac Surgery, University of British Columbia, Vancouver, BC, Canada"},{"name":"Division of Critical Care, University of British Columbia, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Fava","sequence":"additional","affiliation":[{"name":"Royal Columbian Hospital, New Westminster, BC, Canada"},{"name":"Division of Critical Care, University of British Columbia, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob","family":"Sharpe","sequence":"additional","affiliation":[{"name":"Royal Columbian Hospital, New Westminster, BC, Canada"},{"name":"Division of Critical Care, University of British Columbia, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0743-128X","authenticated-orcid":false,"given":"Kamen","family":"Valchanov","sequence":"additional","affiliation":[{"name":"Royal Columbian Hospital, New Westminster, BC, Canada"},{"name":"Department of Anesthesia, University of British Columbia, Vancouver, BC, Canada"},{"name":"Department of Anaesthesia and Perioperative Medicine, Singapore General Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3831-8789","authenticated-orcid":false,"given":"Hossein","family":"Shayan","sequence":"additional","affiliation":[{"name":"Royal Columbian Hospital, New Westminster, BC, Canada"},{"name":"Division of Cardiac Surgery, University of British Columbia, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,2,16]]},"reference":[{"key":"bibr1-02676591231157200","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2018.05.007"},{"key":"bibr2-02676591231157200","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.005583"},{"key":"bibr3-02676591231157200","doi-asserted-by":"publisher","DOI":"10.1093\/ehjcr\/ytaa085"},{"key":"bibr4-02676591231157200","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2018.07.344"},{"key":"bibr5-02676591231157200","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.06.014"},{"key":"bibr6-02676591231157200","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3181f22b5a"},{"key":"bibr7-02676591231157200","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezu201"},{"key":"bibr8-02676591231157200","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2015.04.025"}],"container-title":["Perfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02676591231157200","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/02676591231157200","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02676591231157200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T17:32:52Z","timestamp":1777656772000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/02676591231157200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,16]]},"references-count":8,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1177\/02676591231157200"],"URL":"https:\/\/doi.org\/10.1177\/02676591231157200","relation":{},"ISSN":["0267-6591","1477-111X"],"issn-type":[{"value":"0267-6591","type":"print"},{"value":"1477-111X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,16]]}}}