{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:31:51Z","timestamp":1777915911828,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,2,26]],"date-time":"2023-02-26T00:00:00Z","timestamp":1677369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Meijer Heart and Vascular Institute"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perfusion"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Del Nido cardioplegia (DN) is gaining acceptance in adult cardiac surgery but there is paucity of experimental data regarding its efficacy. We set out to assess the safety and efficacy of single-dose DN with and without topical cooling (TC) versus multi-dose blood cardioplegia (BC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty-two healthy adult sheep had pressure-volume (PV) catheters placed in the left (LV) and right (RV) ventricle. Animals were assigned to receive cold (4\u00b0C) antegrade solution for a 60-min arrest using: (1) multi-dose (every 20\u00a0min) BC with TC ( n = 11), (2) single-dose DN with TC (DN-C, n = 10), or (3) single-dose DN without TC (DN-H, n = 11). LV and RV PV-derived indexes, epicardial echocardiographic strains, and blood samples were acquired before CPB and at 1, 2, and 3\u00a0h of reperfusion. Dobutamine bolus (2.5\u00a0\u03bcg) was given after 3\u00a0h to test for myocardial reserve.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Time to rhythm restoration was shortest (54 \u00b1 29\u00a0s, 118 \u00b1 167\u00a0s, and 172 \u00b1 170\u00a0s for DN-H, DN-C, and BC, respectively; p = 0.024) and number of shocks lowest (1.7 \u00b1 1.8, 3.6 \u00b1 2.8, and 5.6 \u00b1 4.6 for DN-H, DN-C, and BC, respectively; p = 0.020) in DN-H group. Hemodynamic, load-independent myocardial function, echocardiographic, and metabolic data revealed only slight differences between groups. Troponin I levels did not differ between groups. With dobutamine, preload-recruitable stroke work of both LV (136 \u00b1 50%, 131 \u00b1 31%, 142 \u00b1 58% for BC, DN-C and DN-H, respectively; p = 0.993) and RV (161 \u00b1 67%, 185 \u00b1 45%, 166 \u00b1 75% for BC, DN-C and DN-H respectively; p = 0.580) increased similarly.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Single-dose DN cardioplegia with or without topical cooling offered comparable biventricular myocardial protection to multi-dose BC for a 60-min arrest in sheep.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02676591231159507","type":"journal-article","created":{"date-parts":[[2023,2,26]],"date-time":"2023-02-26T21:35:40Z","timestamp":1677447340000},"page":"766-775","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Myocardial protection using single dose del Nido Cardioplegia with and without topical cooling"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4526-2843","authenticated-orcid":false,"given":"Marcin","family":"Malinowski","sequence":"first","affiliation":[{"name":"Division of Cardiothoracic Surgery, Spectrum Health, Grand Rapids, MI, USA"},{"name":"Department of Cardiac Surgery, Medical University of Silesia, School of Medicine in Katowice, Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Solarewicz","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, Spectrum Health, Grand Rapids, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Farley","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, Spectrum Health, Grand Rapids, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Rios","family":"Salcido","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Spectrum Health, Grand Rapids, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jared","family":"Bush","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, Spectrum Health, Grand Rapids, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"MacDoughall","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, Spectrum Health, Grand Rapids, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Bromberg-White","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, Spectrum Health, Grand Rapids, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasz A","family":"Timek","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, Spectrum Health, Grand 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USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,2,26]]},"reference":[{"key":"bibr1-02676591231159507","doi-asserted-by":"publisher","DOI":"10.1177\/0267659112453754"},{"key":"bibr2-02676591231159507","doi-asserted-by":"publisher","DOI":"10.1051\/ject\/201244098"},{"key":"bibr3-02676591231159507","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.12597"},{"key":"bibr4-02676591231159507","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2014.10.085"},{"key":"bibr5-02676591231159507","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2015.12.058"},{"key":"bibr6-02676591231159507","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2019.07.109"},{"key":"bibr7-02676591231159507","doi-asserted-by":"publisher","DOI":"10.33963\/KP.14964"},{"key":"bibr8-02676591231159507","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2020.01.022"},{"key":"bibr9-02676591231159507","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2017.09.146"},{"key":"bibr10-02676591231159507","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2019.05.083"},{"key":"bibr11-02676591231159507","doi-asserted-by":"publisher","DOI":"10.1053\/j.semtcvs.2019.08.003"},{"key":"bibr12-02676591231159507","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2013.05.032"},{"key":"bibr13-02676591231159507","doi-asserted-by":"publisher","DOI":"10.14740\/cr500e"},{"key":"bibr14-02676591231159507","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)38625-8"},{"key":"bibr15-02676591231159507","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.61.2.256"},{"key":"bibr16-02676591231159507","doi-asserted-by":"publisher","DOI":"10.5761\/atcs.oa.18-00087"},{"key":"bibr17-02676591231159507","doi-asserted-by":"publisher","DOI":"10.1053\/j.semtcvs.2017.10.001"},{"key":"bibr18-02676591231159507","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.52.6.1105"},{"key":"bibr19-02676591231159507","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2011.03.009"},{"key":"bibr20-02676591231159507","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(10)80011-7"},{"key":"bibr21-02676591231159507","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-009-9477-7"},{"key":"bibr22-02676591231159507","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2019.08.026"},{"key":"bibr23-02676591231159507","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(96)00150-2"},{"key":"bibr24-02676591231159507","doi-asserted-by":"publisher","DOI":"10.1177\/0267659116661051"},{"key":"bibr25-02676591231159507","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2010.06.004"},{"key":"bibr26-02676591231159507","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.67.2.174"},{"key":"bibr27-02676591231159507","doi-asserted-by":"publisher","DOI":"10.5830\/CVJA-2014-005"},{"key":"bibr28-02676591231159507","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)36762-5"},{"key":"bibr29-02676591231159507","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivu259"}],"container-title":["Perfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02676591231159507","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/02676591231159507","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02676591231159507","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T17:32:57Z","timestamp":1777656777000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/02676591231159507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,26]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1177\/02676591231159507"],"URL":"https:\/\/doi.org\/10.1177\/02676591231159507","relation":{},"ISSN":["0267-6591","1477-111X"],"issn-type":[{"value":"0267-6591","type":"print"},{"value":"1477-111X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,26]]}}}