{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:05:47Z","timestamp":1787018747073,"version":"build-2736575974"},"reference-count":21,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T00:00:00Z","timestamp":1678060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perfusion"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>We hypothesized that perioperative fibrinogen level, platelet count, and rotational thromboelastometry (ROTEM) data values decrease in proportion to cardiopulmonary bypass (CPB) time, particularly in patients who underwent deep hypothermic circulatory arrest (DHCA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 160 patients were enrolled and divided into the following three groups depending on CPB time: &lt;2-h, 2\u2013 3-h, and &gt;3-h groups. Blood samples were obtained during CPB weaning. Platelet count, ROTEM data, fibrinogen level, and antithrombin level were determined. For propensity matching, we selected 15 patients who underwent DHCA and 15 patients who did not undergo DHCA and used propensity scores to match CPB time and other characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The &lt;2-h, 2\u20133-h, and &gt;3-h groups included 74, 63, and 23 patients, respectively. No significant differences in platelet count and fibrinogen level were observed between the groups. Antithrombin level and amplitude of clot firmness at 10\u00a0min in the EXTEM and FIBTEM tests were lowest in the &gt;3-h group. Similarly, blood loss volume and transfusion volume were highest in the &gt;3-h group. Significant differences in platelet count, ROTEM data, lowest esophageal and bladder temperatures, and transfusion volume were observed between patients who underwent DHCA and patients who did not undergo DHCA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The longer the CPB time, the greater the perioperative blood loss volume and transfusion volume, particularly if CPB time is greater than 3\u00a0hours. Sub-group analysis revealed that DHCA affects perioperative platelet count and function as well as blood loss volume.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02676591231161762","type":"journal-article","created":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T16:32:45Z","timestamp":1678120365000},"page":"816-822","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Relationship between perioperative cardiopulmonary bypass time, platelet count, fibrinogen level, rotational thromboelastometry data, antithrombin level, and blood loss volume and the effects of deep hypothermic circulatory arrest: An observational study"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0052-1020","authenticated-orcid":false,"given":"M","family":"Kodaka","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, Tokyo Women\u2019s Medical University Medical Center Adachi, Adachi-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Ichikawa","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, Tokyo Women\u2019s Medical University Medical Center Adachi, Adachi-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Komori","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, Tokyo Women\u2019s Medical University Medical Center Adachi, Adachi-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,3,6]]},"reference":[{"key":"bibr1-02676591231161762","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(16)40641-9"},{"key":"bibr2-02676591231161762","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181ce1ffa"},{"key":"bibr3-02676591231161762","first-page":"131","volume":"64","author":"Ichikawa J","year":"2015","journal-title":"Masui"},{"key":"bibr4-02676591231161762","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e31823497dd"},{"key":"bibr5-02676591231161762","first-page":"244","volume":"16","author":"Ichikawa J","year":"2018","journal-title":"Blood Transfus"},{"key":"bibr6-02676591231161762","doi-asserted-by":"publisher","DOI":"10.1177\/1076029615597061"},{"key":"bibr7-02676591231161762","first-page":"123","volume":"71","author":"Wang J","year":"2013","journal-title":"Neth J Med"},{"key":"bibr8-02676591231161762","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.13.1464"},{"key":"bibr9-02676591231161762","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeq058"},{"key":"bibr10-02676591231161762","doi-asserted-by":"publisher","DOI":"10.11478\/jscva.2013-2-007"},{"key":"bibr11-02676591231161762","unstructured":"Ministry of Health, Labor and Welfare. Guidelines for use of blood products (revised), www.mhlw.go.jp\/new-info\/kobetu\/iyaku\/kenketsugo\/5tekisei3b01.html#01 (accessed 26 June 2021)."},{"key":"bibr12-02676591231161762","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(92)90767-X"},{"key":"bibr13-02676591231161762","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2017.06.072"},{"key":"bibr14-02676591231161762","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-019-0875-7"},{"key":"bibr15-02676591231161762","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2010.04.043"},{"key":"bibr16-02676591231161762","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e3181608f7c"},{"key":"bibr17-02676591231161762","doi-asserted-by":"publisher","DOI":"10.1097\/01.TA.0000064328.97941.FC"},{"key":"bibr18-02676591231161762","doi-asserted-by":"publisher","DOI":"10.1111\/anae.13765"},{"key":"bibr19-02676591231161762","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.023956"},{"key":"bibr20-02676591231161762","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aex100"},{"key":"bibr21-02676591231161762","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-020-02810-x"}],"container-title":["Perfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02676591231161762","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/02676591231161762","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02676591231161762","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T17:33:02Z","timestamp":1777656782000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/02676591231161762"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,6]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1177\/02676591231161762"],"URL":"https:\/\/doi.org\/10.1177\/02676591231161762","relation":{},"ISSN":["0267-6591","1477-111X"],"issn-type":[{"value":"0267-6591","type":"print"},{"value":"1477-111X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,6]]}}}