{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:31:57Z","timestamp":1777915917259,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T00:00:00Z","timestamp":1678406400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Huanhua Talent for Discipline Backbone of Sichuan Provincial People\u2019s Hospital","award":["SY2022017"],"award-info":[{"award-number":["SY2022017"]}]},{"name":"Sichuan Science and Technology Program","award":["[2021JDJQ0041, 2020YFQ0060]"],"award-info":[{"award-number":["[2021JDJQ0041, 2020YFQ0060]"]}]},{"name":"National Natural Science and Technology Foundation of China","award":["[81800274]"],"award-info":[{"award-number":["[81800274]"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perfusion"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Acknowledging lacking of consensus exist in total aortic arch (TAA) surgery for acute type A aortic dissection (AAD), this study aimed to investigate the neurologic injury rate between bilateral and unilateral cerebrum perfusion on the specific population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 595 AAD patients other than Marfan syndrome receiving TAA surgery since March 2013 to March 2022 were included. Among them, 276 received unilateral cerebral perfusion (via right axillary artery, RCP) and 319 for bilateral cerebral perfusion (BCP). The primary outcome was neurologic injury rate. Secondary outcomes were 30-day mortality, serum inflammation response (high sensitivity C reaction protein, hs-CRP; Interleukin-6, IL-6; cold-inducible RNA binding protein, CIRBP) and neuroprotection (RNA-binding motif 3, RBM3) indexes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The BCP group reported a significantly lower permanent neurologic deficits [odds ratio: 0.481, Confidence interval (CI): 0.296\u20130.782, p = 0.003] and 30-day mortality (odds ratio: 0.353, CI: 0.194\u20130.640, p &lt; 0.001) than those received RCP treatment. There were also lower inflammation cytokines (hr-CRP: 114 \u00b1 17 vs. 101 \u00b1 16\u00a0mg\/L; IL-6: 130 [103,170] vs. 81 [69,99] pg\/ml; CIRBP: 1076 [889, 1296] vs. 854 [774, 991] pg\/ml, all p &lt; 0.001), but a higher neuroprotective cytokine (RBM3: 4381 \u00b1 1362 vs 2445 \u00b1 1008\u00a0pg\/mL, p &lt; 0.001) at 24\u00a0h after procedure in BCP group. Meanwhile, BCP resulted in a significantly lower Acute Physiology, Age and Chronic Health Evaluation (APACHE) \u2161score (18 \u00b1 6 vs 17 \u00b1 6, p &lt; 0.001) and short stay in intensive care unit (4 [3,5] vs. 3 [2,3] days, p &lt; 0.001) and hospital (16 \u00b1 4 vs 14 \u00b1 3\u00a0days, p &lt; 0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This present study indicated that BCP compared with RCP was associated with lower permanent neurologic deficits and 30-day mortality in AAD patients other than Marfan syndrome receiving TAA surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02676591231161919","type":"journal-article","created":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T17:05:59Z","timestamp":1678467959000},"page":"1070-1079","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["A comparison of bilateral and unilateral cerebral perfusion for total arch replacement surgery for non-marfan, type A aortic dissection"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5821-359X","authenticated-orcid":false,"given":"Qin","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, Affiliated Hospital of University of Electronic Science and Technology, Sichuan Provincial People\u2019s Hospital, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keli","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Affiliated 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengshou","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Chinese Academy of Medical Sciences and Peking Union Medical College, Fuwai Hospital, Beijing, 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