{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:05:57Z","timestamp":1792451157120,"version":"4.5.0"},"reference-count":45,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T00:00:00Z","timestamp":1689724800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["4K12HL119994-04"],"award-info":[{"award-number":["4K12HL119994-04"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perfusion"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Reducing cardiopulmonary bypass (CPB) induced inflammatory injury is a potentially important strategy for children undergoing multiple operations for single ventricle palliation. We sought to characterize the soluble receptor for advanced glycation end products (sRAGE), a protein involved in acute lung injury and inflammation, in pediatric patients with congenital heart disease and hypothesized that patients undergoing single ventricle palliation would have higher levels of sRAGE following bypass than those with biventricular physiologies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a prospective, observational study of children undergoing CPB. Plasma samples were obtained before and after bypass. sRAGE levels were measured and compared between those with biventricular and single ventricle heart disease using descriptive statistics and multivariate analysis for risk factors for lung injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>sRAGE levels were measured in 40 patients: 19 with biventricular and 21 with single ventricle heart disease. Children undergoing single ventricle palliation had a higher factor and percent increase in sRAGE levels when compared to patients with biventricular circulations (4.6 vs. 2.4, p = 0.002) and (364% vs. 181%, p = 0.014). The factor increase in sRAGE inversely correlated with the patient\u2019s preoperative oxygen saturation (Pearson correlation (r) = \u22120.43, p = 0.005) and was positively associated with red blood cell transfusion (coefficient = 0.011; 95% CI: 0.004, 0.017; p = 0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Children with single ventricle physiology have greater increase in sRAGE following CPB as compared to children undergoing biventricular repair. Larger studies delineating the role of sRAGE in children undergoing single ventricle palliation may be beneficial in understanding how to prevent complications in this high-risk population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02676591231189357","type":"journal-article","created":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T04:39:14Z","timestamp":1689741554000},"page":"1314-1322","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Children with single ventricle heart disease have a greater increase in sRAGE after cardiopulmonary bypass"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5158-3953","authenticated-orcid":false,"given":"Bonnie A","family":"Brooks","sequence":"first","affiliation":[{"name":"Division of Pediatric Critical Care Medicine, Mattel Children\u2019s Hospital, University of California Los Angeles, Los Angeles, CA, USA"},{"name":"Division of Critical Care Medicine, Children\u2019s National Hospital, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pranava","family":"Sinha","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiac Surgery, M Health Fairview University of Minnesota, Minneapolis MN, USA"},{"name":"Division of Cardiovascular Surgery, Children\u2019s National Hospital, George Washington University School of Medicine and Health Sciences, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J","family":"Staffa","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Critical Care and Pain Medicine, Harvard University, Boston Children\u2019s Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marni B","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Diego, CA, USA"},{"name":"Division of Biostatistics and Study Methodology, Children\u2019s National Hospital, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J","family":"Freishtat","sequence":"additional","affiliation":[{"name":"Center for Genetic Medicine Research, Children\u2019s National Hospital, Washington, DC, USA"},{"name":"Departments of Pediatrics, Emergency Medicine, and Genomics & Precision Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason T","family":"Patregnani","sequence":"additional","affiliation":[{"name":"Division of Pediatric Critical Care Medicine, Maine Medical Center, Tufts University School of Medicine, Barbara Bush Children\u2019s Hospital, Portland, ME, USA"},{"name":"Division of Pediatric Cardiac Critical Care, Children\u2019s National Hospital, George Washington University School of Medicine, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,7,19]]},"reference":[{"key":"bibr1-02676591231189357","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.029375"},{"key":"bibr2-02676591231189357","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0912461"},{"key":"bibr3-02676591231189357","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8191.2009.00823.x"},{"key":"bibr4-02676591231189357","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2006.02.073"},{"key":"bibr5-02676591231189357","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpa.2015.03.006"},{"key":"bibr6-02676591231189357","doi-asserted-by":"publisher","DOI":"10.1253\/jcj.60.355"},{"key":"bibr7-02676591231189357","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1971452"},{"key":"bibr8-02676591231189357","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000000541"},{"key":"bibr9-02676591231189357","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-006-0934-y"},{"key":"bibr10-02676591231189357","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-018-2023-4"},{"key":"bibr11-02676591231189357","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070200"},{"key":"bibr12-02676591231189357","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200204000-00018"},{"key":"bibr13-02676591231189357","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-005-0688-7"},{"key":"bibr14-02676591231189357","first-page":"40","volume":"23","author":"Oczypok EA","year":"2017","journal-title":"Paediatr Respir Rev"},{"key":"bibr15-02676591231189357","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.12.2792"},{"key":"bibr16-02676591231189357","doi-asserted-by":"publisher","DOI":"10.1042\/bj20021371"},{"key":"bibr17-02676591231189357","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M409782200"},{"key":"bibr18-02676591231189357","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.222.105"},{"key":"bibr19-02676591231189357","doi-asserted-by":"publisher","DOI":"10.1136\/tsaco-2017-000121"},{"key":"bibr20-02676591231189357","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-016-4352-1"},{"key":"bibr21-02676591231189357","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000009929"},{"key":"bibr22-02676591231189357","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00045910"},{"key":"bibr23-02676591231189357","doi-asserted-by":"publisher","DOI":"10.1186\/cc11354"},{"key":"bibr24-02676591231189357","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000005373"},{"key":"bibr25-02676591231189357","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep199"},{"issue":"6","key":"bibr26-02676591231189357","first-page":"957","volume":"60","author":"El-Seify MY","year":"2014","journal-title":"Clin Lab"},{"key":"bibr27-02676591231189357","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1278352"},{"key":"bibr28-02676591231189357","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201501-0020OC"},{"key":"bibr29-02676591231189357","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000001032"},{"key":"bibr30-02676591231189357","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.149.3.7509706"},{"key":"bibr31-02676591231189357","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000002950"},{"key":"bibr32-02676591231189357","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.118201"},{"key":"bibr33-02676591231189357","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2002.122536"},{"key":"bibr34-02676591231189357","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(05)80075-2"},{"key":"bibr35-02676591231189357","doi-asserted-by":"publisher","DOI":"10.1177\/0267659116681435"},{"key":"bibr36-02676591231189357","doi-asserted-by":"publisher","DOI":"10.3109\/01902148.2012.662667"},{"key":"bibr37-02676591231189357","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2008-0265OC"},{"key":"bibr38-02676591231189357","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(99)70256-4"},{"key":"bibr39-02676591231189357","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(99)70257-6"},{"key":"bibr40-02676591231189357","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200901-0118OC"},{"key":"bibr41-02676591231189357","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00278.2012"},{"key":"bibr42-02676591231189357","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000002851"},{"key":"bibr43-02676591231189357","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e3181e30d43"},{"key":"bibr44-02676591231189357","doi-asserted-by":"publisher","DOI":"10.1177\/0267659113517922"},{"key":"bibr45-02676591231189357","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000001603"}],"container-title":["Perfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02676591231189357","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/02676591231189357","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02676591231189357","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T17:33:29Z","timestamp":1777656809000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/02676591231189357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,19]]},"references-count":45,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1177\/02676591231189357"],"URL":"https:\/\/doi.org\/10.1177\/02676591231189357","relation":{},"ISSN":["0267-6591","1477-111X"],"issn-type":[{"value":"0267-6591","type":"print"},{"value":"1477-111X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,19]]}}}