{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:55:30Z","timestamp":1792176930051,"version":"4.4.0"},"reference-count":24,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T00:00:00Z","timestamp":1692662400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perfusion"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>del Nido cardioplegia is utilized for myocardial protection in adult patients undergoing cardiac surgery; however, no standardized re-dosing protocol exists. We describe perfusion characteristics and clinical outcomes in adult cardiac surgery patients who were re-dosed with del Nido cardioplegia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Chart review was performed for adult patients undergoing cardiac surgery (specific inclusion\/exclusion criteria below) who received exactly two doses of del Nido cardioplegia from 2012 to 2019; n = 542 patients. The main outcome was a composite endpoint comprised of operative mortality, myocardial infarction, post-operative cardiac support device (CSD), and postoperative decrease in ejection fraction (EF), which was analyzed via multivariable logistic regression (MVLR). A secondary analysis evaluated postoperative vasoactive-inotropic scores (VIS) via gamma log link regression (GLLR) as a more physiologic indication of myocardial recovery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>MVLR demonstrated that increased total cardiopulmonary bypass (CPB) time was associated with a positive composite outcome ( p &lt; .001), whereas time between doses ( p = .237) and the volume of each dose was not ( p = .626). GLLR also demonstrated that prolonged CBP, decreased EF, congestive heart failure at time of surgery, and low hematocrit at the start of the surgery were all associated with higher VIS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this retrospective study, variations in re-dosing strategy for del Nido cardioplegia do not affect postoperative outcomes and increased CPB time is associated with increased operative mortality, myocardial infarction, need for post-operative CSDs, and reduced postoperative EF, and increased VIS, irrespective of the re-dosing strategy. Further studies are warranted to to identify additional patient and operative characteristics that predispose to complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02676591231197524","type":"journal-article","created":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T02:45:05Z","timestamp":1692758705000},"page":"1415-1423","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Re-Dosing del Nido cardioplegia in adult cardiac surgery: Perfusion characteristics and outcomes--Is there an optimal redosing strategy?"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1665-065X","authenticated-orcid":false,"given":"Alexander P","family":"Kossar","sequence":"first","affiliation":[{"name":"Division of Cardiothoracic Surgery, NewYork Presbyterian Hospital\/Columbia University Irving Medical Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Nemeth","sequence":"additional","affiliation":[{"name":"Columbia HeartSource, Center for Innovation and Outcomes Research, Columbia University Irving Medical Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaagnik D","family":"Kosuri","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, NewYork Presbyterian Hospital\/Columbia University Irving Medical Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte E","family":"Kazzi","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, NewYork Presbyterian Hospital\/Columbia University Irving Medical Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Honzel","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, NewYork Presbyterian Hospital\/Columbia University Irving Medical Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"D\u2019Angelo","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, NewYork Presbyterian Hospital\/Columbia University Irving Medical Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Spellman","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, NewYork Presbyterian Hospital\/Columbia University Irving Medical Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Takeda","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, NewYork Presbyterian Hospital\/Columbia University Irving Medical Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroo","family":"Takayama","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, NewYork Presbyterian Hospital\/Columbia University Irving Medical Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinayak","family":"Bapat","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, NewYork Presbyterian Hospital\/Columbia University Irving Medical Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Argenziano","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, NewYork Presbyterian Hospital\/Columbia University Irving Medical Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Beck","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, NewYork Presbyterian Hospital\/Columbia University Irving Medical Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig R","family":"Smith","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, NewYork Presbyterian Hospital\/Columbia University Irving Medical Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Kurlansky","sequence":"additional","affiliation":[{"name":"Columbia HeartSource, Center for Innovation and Outcomes Research, Columbia University Irving Medical Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac","family":"George","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, NewYork Presbyterian Hospital\/Columbia University Irving Medical Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,8,22]]},"reference":[{"key":"bibr1-02676591231197524","doi-asserted-by":"publisher","DOI":"10.1177\/1556984519863718"},{"key":"bibr2-02676591231197524","doi-asserted-by":"publisher","DOI":"10.1051\/ject\/201244098"},{"issue":"2","key":"bibr3-02676591231197524","first-page":"114","volume":"15","author":"Sanetra K","year":"2018","journal-title":"Kardiochir Torakochirurgia Pol"},{"issue":"4","key":"bibr4-02676591231197524","first-page":"295","volume":"13","author":"Mishra P","year":"2016","journal-title":"Kardiochir Torakochirurgia Pol"},{"key":"bibr5-02676591231197524","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2014.10.085"},{"key":"bibr6-02676591231197524","doi-asserted-by":"publisher","DOI":"10.1177\/0267659115599453"},{"key":"bibr7-02676591231197524","first-page":"1043","author":"Ziazadeh D","year":"2017","journal-title":"Semin Thorac Cardiovasc 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Quality and Patient Safety Cardiac Services Program. 2019 Data Collection: 12\/1\/2018 - 11\/30\/2019 discharged. Cardiac surgery report, adult (age 18 and over), instructions and data element definitions. Form DOH-2254a. https:\/\/www.health.ny.gov\/forms\/cardiac_surgery\/2019\/doh-2254a_instructions.pdf (accessed 3 June 2020)."},{"key":"bibr18-02676591231197524","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwk052"},{"key":"bibr19-02676591231197524","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2010.04.001"},{"key":"bibr20-02676591231197524","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(96)01039-1"},{"key":"bibr21-02676591231197524","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(98)00725-5"},{"issue":"19","key":"bibr22-02676591231197524","first-page":"III84","volume":"102","author":"Flack JE","year":"2000","journal-title":"Circulation"},{"key":"bibr23-02676591231197524","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2018.11.042"},{"key":"bibr24-02676591231197524","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1999.79.2.609"}],"container-title":["Perfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02676591231197524","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/02676591231197524","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02676591231197524","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T17:33:37Z","timestamp":1777656817000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/02676591231197524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,22]]},"references-count":24,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1177\/02676591231197524"],"URL":"https:\/\/doi.org\/10.1177\/02676591231197524","relation":{},"ISSN":["0267-6591","1477-111X"],"issn-type":[{"value":"0267-6591","type":"print"},{"value":"1477-111X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,22]]}}}