{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T19:53:30Z","timestamp":1783799610454,"version":"3.55.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T00:00:00Z","timestamp":1704412800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perfusion"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>Multisystem inflammatory disease in childhood (MIS-C) is a novel pediatric syndrome after a COVID-19 infection that causes systemic injury, with potential life-threatening hemodynamic compromise requiring Extracorporeal Membrane Oxygenation (ECMO) support. We performed an observational retrospective cohort study in children aged 0-18 years with MIS-C and non-MIS-C myocarditis on ECMO between January 2020 and December 2021, using the ELSO Registry database. We aimed to compare the outcomes of both populations and to identify factors for decreased survival in MIS-C patients on ECMO. The Extracorporeal Life Support Organization (ELSO) Registry reported 310 pediatric ECMO patients with MIS-C (56.1%) and non-MIS-C myocarditis (43.9%). No difference was found in survival to hospital discharge between groups (67.2% for MIS-C vs 69.1% for non-MIS-C myocarditis, p 0.725). Multivariable analysis demonstrated that ECPR and co-infection were significantly associated with decreased survival to hospital discharge in MIS-C patients (OR 0.138, p 0.01 and OR 0.44, p 0.02, respectively). Outcomes of children with MIS-C on ECMO support are similar to those of non-MIS-C myocarditis despite higher infectious, multiorgan dysfunction and respiratory complications accompanying COVID-19 infections. The use of ECMO for MIS-C patients seems to be feasible and safe. Prospective studies on the use of ECMO support in MIS-C patients may improve outcomes in this pediatric population.<\/jats:p>","DOI":"10.1177\/02676591231226290","type":"journal-article","created":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T07:57:27Z","timestamp":1704441447000},"page":"174-182","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["\u201cExtracorporeal membrane oxygenation outcomes in multisystem inflammatory syndrome of childhood \u2013 An extracorporeal life support organization registry study\u201d"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1034-6913","authenticated-orcid":false,"given":"Noah","family":"Miller","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology, University of Tennessee Health Science Center, Le Bonheur Children\u2019s Hospital Memphis, Memphis, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitesh S","family":"Sandhu","sequence":"additional","affiliation":[{"name":"Division of Pediatric Critical Care, University of Tennessee Health Science Center, Le Bonheur Children\u2019s Hospital Memphis, Memphis, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Anton-Martin","sequence":"additional","affiliation":[{"name":"Division of Anesthesia and Critical Care Medicine, Children\u2019s Hospital of Philadelphia, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,1,5]]},"reference":[{"key":"bibr1-02676591231226290","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2020.626182"},{"key":"bibr2-02676591231226290","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000003212"},{"key":"bibr3-02676591231226290","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2020.08.001"},{"key":"bibr4-02676591231226290","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/piaa069"},{"key":"bibr5-02676591231226290","volume-title":"Health Department-Reported Cases of Multisystem Inflammatory Syndrome in Children (MIS-C) in the United States","author":"Centers for Disease Control and Prevention","year":"2022"},{"key":"bibr6-02676591231226290","volume-title":"Information for Healthcare Providers about multisystem inflammatory syndrome in children (MIS-C)","author":"Centers for Disease Control and 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