{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T12:27:06Z","timestamp":1789820826500,"version":"4.0.1"},"reference-count":30,"publisher":"SAGE Publications","issue":"1_suppl","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Italian Ministry of Health - Current research IRCCS"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perfusion"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Extracorporeal membrane oxygenation (ECMO) may act as a driver or propagator of systemic inflammation. In turn, cytokine release can modify thromboelastographic (TEG) tests which are commonly used for anticoagulation monitoring. In this context, antithrombin (AT) supplementation might further modify TEG.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a pre-specified sub-study of the \u201cRandomized Controlled Trial of Antithrombin Supplementation During Extracorporeal Membrane Oxygenation\u201d study (investigator-initiated, randomized, single-blind, two-arm trial) conducted in two Italian ECMO referral ICUs. Adult patients requiring vv-ECMO for respiratory failure and undergoing unfractioned heparin (UFH) administration were enrolled and randomized whether to receive AT supplementation. Plasma samples for cytokine assay (IL-8, IL-10, IL-6, IL-1\u03b2, TNF-\u03b1 and Pro-ADM) and heparinase TEG were collected from every patient before ECMO start, 24\u00a0h and 72\u00a0h after ECMO start, before ECMO removal, and 7\u00a0days after ECMO removal or upon ICU discharge whichever happened first. AT concentration, coagulation and clinical data were collected before ECMO start and at pre-fixed time points.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty-nine patients were enrolled (21 treatments, 18 controls). TEG-R had a weak-to-moderate positive correlation with IL-8, IL-6, IL-10 and TNF-\u03b1 and a moderate positive correlation with Pro-ADM. TEG-ANG showed a weak negative correlation with IL-8, IL-6 and TNF-\u03b1, while TEG-MA negatively correlated with IL-8, TNF-\u03b1 and Pro-ADM. AT supplementation seemed to modify the association between TEG-MA and IL-8, IL-10 and Pro-ADM; conversely, AT did not affect the relationship among TEG-R or TEG-ANG and the studied cytokines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>High concentrations of systemic cytokines correlated with longer reaction times and decreased angle and amplitude at TEG, suggesting that an increase in inflammation is related with hypocoagulability as revealed by thromboelastography.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02676591241237637","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T05:35:25Z","timestamp":1713850525000},"page":"66S-76S","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["The role of inflammation and antithrombin supplementation on thromboelastographic parameters during veno-venous ECMO for respiratory failure"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5470-2978","authenticated-orcid":false,"given":"Andrea","family":"Meli","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Critical Care and Emergency, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"De Falco","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Critical Care and Emergency, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Novembrino","sequence":"additional","affiliation":[{"name":"A. Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Boscolo Anzoletti","sequence":"additional","affiliation":[{"name":"A. Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Arcadipane","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care, IRCCS, UPMC, ISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad alta specializzazione), UPMC Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Panarello","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care, IRCCS, UPMC, ISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad alta specializzazione), UPMC Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Occhipinti","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care, IRCCS, UPMC, ISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad alta specializzazione), UPMC Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Grasselli","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Critical Care and Emergency, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, Milan, Italy"},{"name":"Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Panigada","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Critical Care and Emergency, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,4,23]]},"reference":[{"key":"bibr1-02676591241237637","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-016-4314-7"},{"key":"bibr2-02676591241237637","doi-asserted-by":"crossref","unstructured":"Panigada M. Thromboelastography-based anticoagulation management during extracorporeal membrane oxygenation: a safety and feasibility pilot study. 2018; 8: 7.","DOI":"10.1186\/s13613-017-0352-8"},{"key":"bibr3-02676591241237637","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000004590"},{"key":"bibr4-02676591241237637","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-016-1570-4"},{"key":"bibr5-02676591241237637","doi-asserted-by":"publisher","DOI":"10.1097\/00001721-200203000-00005"},{"key":"bibr6-02676591241237637","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.306853"},{"key":"bibr7-02676591241237637","doi-asserted-by":"publisher","DOI":"10.1038\/srep32188"},{"key":"bibr8-02676591241237637","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2018.01.007"},{"key":"bibr9-02676591241237637","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-20220-8"},{"key":"bibr10-02676591241237637","doi-asserted-by":"publisher","DOI":"10.21037\/atm-20-3651"},{"key":"bibr11-02676591241237637","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2019.11.008"},{"key":"bibr12-02676591241237637","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-017-0238-9"},{"key":"bibr13-02676591241237637","first-page":"1449","volume":"81","author":"Hirata Y","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"bibr14-02676591241237637","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-17227-7"},{"key":"bibr15-02676591241237637","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22084283"},{"key":"bibr16-02676591241237637","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15052"},{"key":"bibr17-02676591241237637","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-019-3386-4"},{"key":"bibr18-02676591241237637","doi-asserted-by":"publisher","DOI":"10.5863\/1551-6776-22.4.266"},{"key":"bibr19-02676591241237637","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10071-23136"},{"key":"bibr20-02676591241237637","doi-asserted-by":"publisher","DOI":"10.5527\/wjn.v2.i2.31"},{"key":"bibr21-02676591241237637","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02869.x"},{"key":"bibr22-02676591241237637","doi-asserted-by":"publisher","DOI":"10.1089\/107999001317205196"},{"key":"bibr23-02676591241237637","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0206123"},{"key":"bibr24-02676591241237637","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102263"},{"key":"bibr25-02676591241237637","doi-asserted-by":"publisher","DOI":"10.1186\/cc5156"},{"key":"bibr26-02676591241237637","doi-asserted-by":"publisher","DOI":"10.1186\/cc5098"},{"key":"bibr27-02676591241237637","doi-asserted-by":"publisher","DOI":"10.1007\/s001340050642"},{"key":"bibr28-02676591241237637","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1992.32692367206.x"},{"key":"bibr29-02676591241237637","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2018.00352"},{"key":"bibr30-02676591241237637","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15020"}],"container-title":["Perfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02676591241237637","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/02676591241237637","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02676591241237637","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T17:34:20Z","timestamp":1777656860000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/02676591241237637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":30,"journal-issue":{"issue":"1_suppl","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1177\/02676591241237637"],"URL":"https:\/\/doi.org\/10.1177\/02676591241237637","relation":{},"ISSN":["0267-6591","1477-111X"],"issn-type":[{"value":"0267-6591","type":"print"},{"value":"1477-111X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4]]}}}