{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T14:34:27Z","timestamp":1787668467495,"version":"build-2736575974"},"reference-count":49,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T00:00:00Z","timestamp":1710460800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perfusion"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Postoperative delirium (POD) has a major impact on patient recovery after cardiac surgery. Although its pathophysiology remains unclear, there could be a correlation between cerebral blood flow (CBF) variations during cardio-pulmonary bypass (CPB) and POD. Our study aimed to evaluate whether variations in on-pump CBF, compared to pre-anesthesia and pre-CPB values, are associated with POD following coronary artery bypass grafting (CABG) surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This prospective observational cohort study included 95 adult patients undergoing elective on-pump CABG surgery. Right middle cerebral artery blood flow velocity (MCAV) was assessed using Transcranial Doppler before anesthesia induction, before CPB and every fifteen minutes during CPB. Pre-anesthesia and pre-CPB values were chosen as baselines. Individual values, measured during CPB, were converted as percentage changes relative to these baselines and named as %MCAV\n                      <jats:sub>0<\/jats:sub>\n                      and %MCAV\n                      <jats:sub>1<\/jats:sub>\n                      , respectively. POD was assessed using the Confusion Assessment Method for ICU (CAM-ICU) during the first 48 post-operative hours and with the 3-Minute Diagnostic Interview for Confusion Assessment Method (3D-CAM) on the fifth post-surgical day.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall POD incidence was 17.9%. At 30\u00a0minutes of CPB, %MCAV\n                      <jats:sub>0<\/jats:sub>\n                      was higher in POD group than in no-POD group ( p = .05). %MCAV\n                      <jats:sub>0<\/jats:sub>\n                      at 45\u00a0minutes of CPB was significantly higher in POD group (87 (\u00b117) %) than in no-POD group (68 (\u00b124) %), p = .04. %MCAV\n                      <jats:sub>1<\/jats:sub>\n                      at 30 and 45\u00a0minutes of CPB were higher in POD group than in no-POD group, at the limit of statistical significance. We found %MCAV\n                      <jats:sub>1<\/jats:sub>\n                      &gt; 100% in POD group, but not in no-POD group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Significant differences in %MCAV\n                      <jats:sub>0<\/jats:sub>\n                      became evident after 30\u00a0minutes of CPB, whereas differences in %MCAV\n                      <jats:sub>1<\/jats:sub>\n                      at 45 minutes of CPB were at limit of statistical significance. In POD group %MCAV\n                      <jats:sub>1<\/jats:sub>\n                      was higher than 100% at 30 and 45\u00a0minutes of CPB, which is supposed to be a sign of cerebral hyperperfusion. Monitoring CBF during CPB could have prognostic value for POD.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02676591241239823","type":"journal-article","created":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T04:12:50Z","timestamp":1710475970000},"page":"440-449","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["The association between cerebral blood flow variations during on-pump coronary artery bypass grafting surgery and postoperative delirium"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6267-0694","authenticated-orcid":false,"given":"Caterina","family":"Sampaolesi","sequence":"first","affiliation":[{"name":"Anesthesia and Intensive Care Unit, Azienda Ospedaliero Universitaria Delle Marche, Ancona, Italy"},{"name":"Cardiosurgical Anesthesia and Intensive Care Unit, Azienda Ospedaliero Universitaria Delle Marche, Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Casarotta","sequence":"additional","affiliation":[{"name":"Anesthesia and Intensive Care Unit, Azienda Ospedaliero Universitaria Delle Marche, Ancona, Italy"},{"name":"Department of Biomedical Sciences and Public Health, Universit\u00e0 Politecnica Delle Marche, Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Gresti","sequence":"additional","affiliation":[{"name":"Cardiosurgical Anesthesia and Intensive Care Unit, Azienda Ospedaliero Universitaria Delle Marche, Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Mariotti","sequence":"additional","affiliation":[{"name":"Anesthesia and Intensive Care Unit, Azienda Ospedaliero Universitaria Delle Marche, Ancona, Italy"},{"name":"Cardiosurgical Anesthesia and Intensive Care Unit, Azienda Ospedaliero Universitaria Delle Marche, Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Pisani","sequence":"additional","affiliation":[{"name":"Cardiosurgical Anesthesia and Intensive Care Unit, Azienda Ospedaliero Universitaria Delle Marche, Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Veccia","sequence":"additional","affiliation":[{"name":"Anesthesia and Intensive Care Unit, Azienda Ospedaliero Universitaria Delle Marche, Ancona, Italy"},{"name":"Cardiosurgical Anesthesia and Intensive Care Unit, Azienda Ospedaliero Universitaria Delle Marche, Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Di Eusanio","sequence":"additional","affiliation":[{"name":"Cardiosurgical Unit, Azienda Ospedaliero Universitaria Delle Marche, Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3508-2670","authenticated-orcid":false,"given":"Pietro Giorgio","family":"Malvindi","sequence":"additional","affiliation":[{"name":"Cardiosurgical Unit, Azienda Ospedaliero Universitaria Delle Marche, Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abele","family":"Donati","sequence":"additional","affiliation":[{"name":"Anesthesia and Intensive Care Unit, Azienda Ospedaliero Universitaria Delle Marche, Ancona, Italy"},{"name":"Department of Biomedical Sciences and Public Health, Universit\u00e0 Politecnica Delle Marche, Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher Maria","family":"M\u00fcnch","sequence":"additional","affiliation":[{"name":"Cardiosurgical Anesthesia and Intensive Care Unit, Azienda Ospedaliero Universitaria Delle Marche, Ancona, 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