{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:33:58Z","timestamp":1787960038805,"version":"build-2784847793"},"reference-count":46,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T00:00:00Z","timestamp":1712534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the Youth Science and Technology Fund of Gansu Province","award":["21JR1RA164"],"award-info":[{"award-number":["21JR1RA164"]}]},{"name":"Innovation Fund of colleges and universities in gansu province","award":["2020B-037"],"award-info":[{"award-number":["2020B-037"]}]},{"name":"National College Student Innovation and Entrepreneurship Training Program","award":["202310730201"],"award-info":[{"award-number":["202310730201"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perfusion"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Exercise-based cardiac rehabilitation (EBCR) improves functional capacity in heart failure (HF). However, data on the effect of EBCR in patients with advanced HF and left ventricular assist devices (LVADs) are limited. This meta-analysis aimed to evaluate the impact of EBCR on the functional ability of LVAD patients by comparing the corresponding outcome indicators between the EBCR and ST groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed, Embase, Clinical Trials, and Cochrane Library databases were searched for studies assessing and comparing the effects of EBCR and standard therapy (ST) in patients following LVAD implantation. Using pre-defined criteria, appropriate studies were identified and selected. Data from selected studies were extracted in a standardized fashion, and a meta-analysis was performed using a fixed-effects model. The protocol was registered on INPLASY (202340073).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 12 trials involving 477 patients were identified. The mean age of the participants was 52.9 years, and 78.6% were male. The initiation of EBCR varied from LVAD implantation during the index hospitalization to 11\u00a0months post-LVAD implantation. The median rehabilitation period ranged from 2\u00a0weeks to 18\u00a0months. EBCR was associated with improved peak oxygen uptake (VO2) in all trials. Quantitative analysis was performed in six randomized studies involving 214 patients (EBCR: n = 130, ST: n = 84). EBCR was associated with a significantly high peak VO2 (weighted mean difference [WMD] = 1.64\u00a0mL\/kg\/min; 95% confidence interval [CI], 0.20-3.08; p = .03). Similarly, 6-min walk distance (6MWD) showed significantly greater improvement in the EBCR group than in the ST group (WMD = 34.54\u00a0m; 95% CI, 12.47-56.42; p = .002) in 266 patients (EBCR, n = 140; ST, n = 126). Heterogeneity was low among the included trials. None of the included studies reported serious adverse events related to EBCR, indicating the safety of EBCR after LVAD implantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrated that EBCR following LVAD implantation is associated with greater improvement in functional capacity compared with ST as reflected by the improved peak VO2 and 6MWD values. Considering the small number of patients in this analysis, further research on the clinical impact of EBCR in LVAD patients is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02676591241245876","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T12:27:10Z","timestamp":1712579230000},"page":"317-327","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Effectiveness of exercise-based cardiac rehabilitation for patients with left ventricular assist device: A systematic review and meta-analysis"],"prefix":"10.1177","volume":"40","author":[{"given":"Yujin","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiology, Lanzhou University Second Hospital, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawen","family":"Wu","sequence":"additional","affiliation":[{"name":"Second Clinical Medical College, Lanzhou University, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilin","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Lanzhou University Second Hospital, Lanzhou University, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijie","family":"Lu","sequence":"additional","affiliation":[{"name":"Second Clinical Medical College, Lanzhou University, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianting","family":"Zhao","sequence":"additional","affiliation":[{"name":"Second Clinical Medical College, Lanzhou University, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanchun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Lanzhou University Second Hospital, Lanzhou University, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Lanzhou University Second Hospital, Lanzhou University, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Lanzhou University Second Hospital, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0821-8875","authenticated-orcid":false,"given":"Yongnan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Lanzhou University Second Hospital, Lanzhou University, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,4,8]]},"reference":[{"key":"bibr1-02676591241245876","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66621-4"},{"key":"bibr2-02676591241245876","doi-asserted-by":"publisher","DOI":"10.1007\/s11897-019-00432-3"},{"issue":"1","key":"bibr3-02676591241245876","first-page":"23","volume":"64","author":"Yun JJ","year":"2009","journal-title":"Minerva Chir"},{"key":"bibr4-02676591241245876","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.035566"},{"key":"bibr5-02676591241245876","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-041217-011015"},{"key":"bibr6-02676591241245876","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.03.055"},{"key":"bibr7-02676591241245876","doi-asserted-by":"publisher","DOI":"10.1007\/s11897-014-0201-0"},{"key":"bibr8-02676591241245876","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.02.014"},{"key":"bibr9-02676591241245876","doi-asserted-by":"publisher","DOI":"10.1016\/j.hfc.2021.01.007"},{"key":"bibr10-02676591241245876","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.26812"},{"key":"bibr11-02676591241245876","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-1743594"},{"key":"bibr12-02676591241245876","doi-asserted-by":"publisher","DOI":"10.1097\/HCR.0000000000000239"},{"key":"bibr13-02676591241245876","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2022.01.023"},{"key":"bibr14-02676591241245876","doi-asserted-by":"publisher","DOI":"10.1177\/2047487318815303"},{"key":"bibr15-02676591241245876","doi-asserted-by":"publisher","DOI":"10.1097\/HCR.0000000000000615"},{"key":"bibr16-02676591241245876","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-018-9695-y"},{"issue":"9","key":"bibr17-02676591241245876","first-page":"CD012222","volume":"9","author":"Yamamoto S","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr18-02676591241245876","volume-title":"Cochrane handbook for systematic reviews of interventions","author":"Higgins J","year":"2011"},{"key":"bibr19-02676591241245876","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(99)00175-4"},{"key":"bibr20-02676591241245876","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-198108000-00001"},{"key":"bibr21-02676591241245876","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00531-3"},{"key":"bibr22-02676591241245876","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(92)90986-6"},{"key":"bibr23-02676591241245876","doi-asserted-by":"publisher","DOI":"10.1097\/01.HCR.0000270696.01635.aa"},{"key":"bibr24-02676591241245876","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.675041"},{"key":"bibr25-02676591241245876","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2003.11.032"},{"key":"bibr26-02676591241245876","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8651(05)70222-8"},{"key":"bibr27-02676591241245876","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(96)90304-X"},{"key":"bibr28-02676591241245876","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.09.013"},{"key":"bibr29-02676591241245876","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.11.001"},{"key":"bibr30-02676591241245876","first-page":"295","volume-title":"American association of cardiovascular and pulmonary rehabilitation 31st annual meeting scientific abstracts","author":"Toufik MH","year":"2019"},{"key":"bibr31-02676591241245876","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0174323"},{"key":"bibr32-02676591241245876","volume-title":"Textbook of work physiology","author":"Astrand PO","year":"1986"},{"key":"bibr33-02676591241245876","doi-asserted-by":"publisher","DOI":"10.1097\/HCR.0000000000000049"},{"key":"bibr34-02676591241245876","doi-asserted-by":"publisher","DOI":"10.1177\/0269215511405229"},{"key":"bibr35-02676591241245876","doi-asserted-by":"publisher","DOI":"10.1097\/HCR.0000000000000342"},{"key":"bibr36-02676591241245876","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2014.06.011"},{"key":"bibr37-02676591241245876","doi-asserted-by":"publisher","DOI":"10.1080\/00015385.2017.1368947"},{"key":"bibr38-02676591241245876","doi-asserted-by":"publisher","DOI":"10.5301\/ijao.5000464"},{"key":"bibr39-02676591241245876","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000569"},{"key":"bibr40-02676591241245876","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.13106"},{"key":"bibr41-02676591241245876","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2020.08.005"},{"key":"bibr42-02676591241245876","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0259927"},{"key":"bibr43-02676591241245876","doi-asserted-by":"publisher","DOI":"10.1111\/aor.12936"},{"key":"bibr44-02676591241245876","doi-asserted-by":"publisher","DOI":"10.12965\/jer.1938124.062"},{"key":"bibr45-02676591241245876","doi-asserted-by":"publisher","DOI":"10.1097\/HCR.0000000000000789"},{"key":"bibr46-02676591241245876","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmrj.2016.05.013"}],"container-title":["Perfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02676591241245876","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/02676591241245876","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02676591241245876","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T17:34:32Z","timestamp":1777656872000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/02676591241245876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,8]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1177\/02676591241245876"],"URL":"https:\/\/doi.org\/10.1177\/02676591241245876","relation":{},"ISSN":["0267-6591","1477-111X"],"issn-type":[{"value":"0267-6591","type":"print"},{"value":"1477-111X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,8]]}}}