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However, in vitro, LAC exhibits paradoxical effects, prolonging clotting times in phospholipid-dependent assays such as Activated Partial Thromboplastin Time (APTT). This unpredictability extends to point-of-care tests like Activated Clotting Time (ACT), which are frequently used to monitor anticoagulation during cardiac surgeries involving cardiopulmonary bypass (CPB). High doses of unfractionated heparin (UFH) are administered in these procedures, but the presence of LAC complicates ACT measurements, creating challenges for both anesthesiologists and surgeons. This case report highlights the clinical implications of LAC in perioperative management, underscoring the difficulties in ensuring adequate anticoagulation during CPB.<\/jats:p>","DOI":"10.1177\/02676591241293010","type":"journal-article","created":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T04:23:32Z","timestamp":1729916612000},"page":"1495-1498","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Lupus anticoagulant and valvular cardiac surgery"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6908-6170","authenticated-orcid":false,"given":"Pooja Bola Rajendra Devendra","family":"Kamath","sequence":"first","affiliation":[{"name":"Department of Anaesthesia, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah L","family":"Braham","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepa J","family":"Arachchillage","sequence":"additional","affiliation":[{"name":"Centre for Haematology, Department of Immunology and Inflammation, Imperial College London, London, UK"},{"name":"Department of Haematology, Imperial College Healthcare NHS Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis","family":"Loja","sequence":"additional","affiliation":[{"name":"Department of Clinical Perfusion Science, Hammersmith Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,10,26]]},"reference":[{"key":"e_1_3_4_2_2","volume-title":"Biochemistry, lupus anticoagulant","author":"Rasool ZS","year":"2022","unstructured":"Rasool ZS, Tiwari V. 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