{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:33:23Z","timestamp":1777916003351,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T00:00:00Z","timestamp":1731715200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"National High Level Hospital Clinical Research Funding","award":["2022-GSP-GG-22"],"award-info":[{"award-number":["2022-GSP-GG-22"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perfusion"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The impact of non heparin-induced thrombocytopenia on the clinical outcomes for pediatric cardiac surgery patients who required veno-arterial extracorporeal membrane support (VA-ECMO) for failure to wean from cardiopulmonary bypass (CPB) is uncertain. This study aimed to investigate the relationship between thrombocytopenia and prognosis in these patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study enrolled 96 pediatric patients (age &lt; 18) who received VA-ECMO directly transitioned from CPB at Fuwai Hospital from January 2010 to June 2020. The association between relative decrease in platelet count (\u25b3PLT) post-ECMO 24\u00a0h and clinical outcomes was explored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were significant differences in Post-ECMO 24\u00a0h platelet counts, platelet count nadir, and duration of platelet decline between the survivors and non-survivors in CPB-ECMO groups. A positive correlation was found between \u25b3PLT post-ECMO 24\u00a0h and plasma-free hemoglobin (pFHb) (\n                      <jats:italic>p<\/jats:italic>\n                      = .014, r = 0.305), peak serum creatinine (\n                      <jats:italic>p<\/jats:italic>\n                      = .016, r = 0.299), peak AST (\n                      <jats:italic>p<\/jats:italic>\n                      = .014, r = 0.302), duration of platelet transfusion (\n                      <jats:italic>p<\/jats:italic>\n                      = .032, r = 0.270),The \u25b3PLT post-ECMO 24\u00a0h had predictive value on in-hospital mortality [(\n                      <jats:italic>p<\/jats:italic>\n                      &lt; .001, AUROC = 0.781 (95% CI: 0.670\u20130.892)], massive bleeding (\n                      <jats:italic>p<\/jats:italic>\n                      = .001, AUROC 95% CI: 0.627\u20130.870), hemolysis (\n                      <jats:italic>p<\/jats:italic>\n                      = .046, AUROC 95% CI: 0.510\u20130.780), and nosocomial infection (\n                      <jats:italic>p<\/jats:italic>\n                      = .020, AUROC 95% CI: 0.536\u20130.801). Multivariate logistic regression showed that \u25b3PLT post-ECMO 24\u00a0h was associated with in-hospital mortality and hemolysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The relative early decrease in platelet count 24\u00a0h following transition to ECMO is associated with increased patient mortality, and is positively associated with adverse outcomes in pediatric cardiac surgery patients transferred from CPB to ECMO. Moreover, this decline rate can predict in-hospital survival, major bleeding, hemolysis, and hospital-acquired infections.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02676591241301614","type":"journal-article","created":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T09:59:16Z","timestamp":1731751156000},"page":"1405-1414","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["The early decline in platelet count is associated with increased adverse outcomes in non heparin-induced thrombocytopenia pediatric patients undergoing VA-ECMO"],"prefix":"10.1177","volume":"40","author":[{"given":"Yu","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Cardiopulmonary Bypass, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences &amp; Peking Union Medical College Fuwai Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"He","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiopulmonary Bypass, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences &amp; Peking Union Medical College Fuwai Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Cardiopulmonary Bypass, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences &amp; Peking Union Medical College Fuwai Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3422-0100","authenticated-orcid":false,"given":"Peiyao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhangyu","family":"Lin","sequence":"additional","affiliation":[{"name":"Cardiometabolic Medicine Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenting","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiopulmonary Bypass, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences &amp; Peking Union Medical College Fuwai Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3189-7263","authenticated-orcid":false,"given":"Peng","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiopulmonary Bypass, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences &amp; Peking Union Medical College Fuwai Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6025-449X","authenticated-orcid":false,"given":"Jinping","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiopulmonary Bypass, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences &amp; Peking Union Medical College Fuwai Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,11,16]]},"reference":[{"key":"e_1_3_6_2_2","first-page":"955","article-title":"Extracorporeal life support organization (ELSO) guidelines for follow-up after neonatal and pediatric extracorporeal membrane oxygenation","volume":"67","author":"Ijsselstijn H","year":"2021","unstructured":"Ijsselstijn H, Schiller RM, Holder C, et al. 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