{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:33:26Z","timestamp":1777916006754,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T00:00:00Z","timestamp":1732233600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perfusion"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:p>\n                    <jats:italic>Background:<\/jats:italic>\n                    Q-Fever is a rare condition with an often insidious presentation. Endocarditis is a serious complication of up to 5% of Q-Fever cases, with a higher incidence and mortality in patients with prosthetic valves.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Case-history:<\/jats:italic>\n                    A 67-year-old man presented with a 6-weeks history of breathlessness on a background of previous bioprosthetic aortic valve replacement in 2018. Subsequent echocardiograms showed severe eccentric aortic regurgitation, a 2\u00a0cm vegetation, and severely impaired biventricular function. Routine blood cultures were negative, but later PCR testing for non-culturable microorganisms, performed due to the high probability of endocarditis, was positive for\n                    <jats:italic>Coxiella Burnetii<\/jats:italic>\n                    . The patient denied any recent constitutional symptoms and previous exposure to animal reservoirs. He underwent a successful urgent redo sternotomy and aortic valve replacement with a bioprosthesis. Prosthetic valve PCR testing was positive for\n                    <jats:italic>Coxiella Burnetii<\/jats:italic>\n                    , and he completed a long antibiotic course with follow-up serology to guide therapy. Clinic follow-up 3\u00a0months later showed good recovery with no complications.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions:<\/jats:italic>\n                    This case emphasises the high index of suspicion and routine screening needed in culture-negative cases to diagnose Q-Fever endocarditis, especially in the absence of acute symptoms and exposure to known sources of transmission. The complexities in management and timing of surgery are discussed.\n                  <\/jats:p>","DOI":"10.1177\/02676591241303313","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T23:45:13Z","timestamp":1732319113000},"page":"1521-1524","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Q-Fever endocarditis: Prosthetic valve infection in the absence of zoonotic exposure"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2747-3900","authenticated-orcid":false,"given":"Walid","family":"Mohamed","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, Southampton General Hospital, Southampton, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"Dihmis","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Southampton General Hospital, Southampton, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Thirukumaran","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Southampton General Hospital, Southampton, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suvitesh","family":"Luthra","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Southampton General Hospital, Southampton, UK"},{"name":"Faculty of Medicine, University of Southampton, Southampton, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,11,22]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/vetsci4020028"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0828-282X(06)70295-1"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.4065\/79.2.253"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1993.00410050074010"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.12.4.518"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1086\/313753"},{"key":"e_1_3_4_8_2","first-page":"29","article-title":"A zoonotic cause of blood culture-negative infective endocarditis in Belgium: case report and review of the literature on Q fever","volume":"6","author":"H\u00e9lo\u00efse VN","year":"2022","unstructured":"H\u00e9lo\u00efse VN, Marcella M, Marielle M, et al. A zoonotic cause of blood culture-negative infective endocarditis in Belgium: case report and review of the literature on Q fever. IDCases 2022; Aug 6; 29.","journal-title":"IDCases"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1220205"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad193"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2022-321791"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(10)70135-3"}],"container-title":["Perfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02676591241303313","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/02676591241303313","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02676591241303313","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T17:35:32Z","timestamp":1777656932000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/02676591241303313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,22]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1177\/02676591241303313"],"URL":"https:\/\/doi.org\/10.1177\/02676591241303313","relation":{},"ISSN":["0267-6591","1477-111X"],"issn-type":[{"value":"0267-6591","type":"print"},{"value":"1477-111X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,22]]}}}