{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:33:27Z","timestamp":1777916007707,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:00:00Z","timestamp":1733961600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perfusion"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>There is no consensus on the dose of heparin to be used intraoperatively in cardiac myxomas, so the goal of this study was to look into the differences in the clinical effects on the perioperative period of patients with cardiac myxomas when different doses of heparin were used intraoperatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Analysis<\/jats:title>\n                    <jats:p>70 patients who had cardiac myxomas excision via cardiopulmonary bypass between January 2024 and July 2024. The 70 patients were separated into two groups based on the heparin dose administered prior to cardiopulmonary bypass heparinization. 42 patients in group A had a dose of \u2264400\u00a0U\/kg, while 28 patients in group B received a dose of &gt;400\u00a0U\/kg.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>\n                      PT, INR, and APTT were significantly prolonged in patients with cardiac myxomas in group A in the postoperative period 24\u00a0h after surgery, which was statistically significant (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .05) compared with that in group B. Intraoperative heparin dose appeared to influence changes in coagulation at 24\u00a0h postoperatively, but was mainly dominated by APTT. Also, heparinized doses showed a weak positive correlation with 24-h postoperative drainage volume. In addition, the dimension of the cardiac myxomas appeared to have some correlation with the patient\u2019s preoperative APTT and age.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>When patients with cardiac myxomas were heparinized intraoperatively with varying doses of heparin, the enhancement of coagulation in the 24\u00a0h after surgery was more pronounced in the group given higher doses of heparin, and endogenous coagulation pathways were activated much more than exogenous coagulation pathways in the 24\u00a0h after surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02676591241307572","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T10:23:38Z","timestamp":1733999018000},"page":"1487-1494","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A retrospective investigation of varied dose of heparin for cardiopulmonary bypass for repair of cardiac myxomas"],"prefix":"10.1177","volume":"40","author":[{"given":"Dengzhi","family":"Wei","sequence":"first","affiliation":[{"name":"Graduate School of Zunyi Medical University, Zunyi, China"},{"name":"Department of Cardiac and Great Vascular Surgery, Guizhou Provincial People\u2019s Hospital, Guiyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxu","family":"Wang","sequence":"additional","affiliation":[{"name":"Graduate School of Zunyi Medical University, Zunyi, China"},{"name":"Department of Cardiac and Great Vascular Surgery, Guizhou Provincial People\u2019s Hospital, Guiyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiying","family":"Tian","sequence":"additional","affiliation":[{"name":"Graduate School of Zunyi Medical University, Zunyi, China"},{"name":"Department of Cardiac and Great Vascular Surgery, Guizhou Provincial People\u2019s Hospital, Guiyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6009-0714","authenticated-orcid":false,"given":"Xu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Great Vascular Surgery, Guizhou Provincial People\u2019s Hospital, Guiyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daokang","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Great Vascular Surgery, Guizhou Provincial People\u2019s Hospital, Guiyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yizhu","family":"Shu","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Great Vascular Surgery, Guizhou Provincial People\u2019s Hospital, Guiyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,12,12]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1581"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-47639-y"},{"key":"e_1_3_5_4_2","first-page":"3345","article-title":"Genetic research progress of cardiac myxoma","volume":"20","author":"Hong Y","year":"2020","unstructured":"Hong Y, Liu SZ, Luo R, et al. Genetic research progress of cardiac myxoma. Molecular Cardio of China 2020; 20: 3345\u20133348 (in Chinese).","journal-title":"Molecular Cardio of China"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8320793"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2011.12.052"},{"key":"e_1_3_5_7_2","first-page":"CR105","article-title":"The influence of heparin resistance on postoperative complications in patients undergoing coronary surgery","volume":"18","author":"Knapik P","year":"2012","unstructured":"Knapik P, Ciesla D, Przybylski R, et al. The influence of heparin resistance on postoperative complications in patients undergoing coronary surgery. 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