{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:33:29Z","timestamp":1777916009882,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2025,1,5]],"date-time":"2025-01-05T00:00:00Z","timestamp":1736035200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perfusion"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Compare outcomes of Del Nido (DN) versus conventional blood cardioplegia (BC) in the surgical repair of Tetralogy of Fallot (ToF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Medical databases were searched to identify relevant clinical trials. Meta-analysis was conducted for primary (cardiopulmonary bypass [CPB] and aortic cross-clamp [ACC] times, hospital and intensive care unit [ICU] length of stay [LOS], mechanical ventilation time) and secondary (adverse events, lactate levels, volume of additional cardioplegia) endpoints. Analysis was conducted for DN versus conventional blood cardioplegia, and we performed sensitivity analysis with leave one-out analysis for the primary outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      4 randomized controlled trials were included (\n                      <jats:italic>n<\/jats:italic>\n                      = 275). Mean differences (MD) with 95% confidence intervals (CI) were calculated with a random-effects model. Groups had similar CPB (MD \u22125.76\u00a0minutes; [\u221223.32 to 11.80];\n                      <jats:italic>p<\/jats:italic>\n                      = 0.52) and ACC (MD 3.06\u00a0minutes; [\u221213.64 to 7.52];\n                      <jats:italic>p<\/jats:italic>\n                      = 0.57) times, ICU (MD \u22126.42\u00a0hours; [\u221225.62 to 12.78];\n                      <jats:italic>p<\/jats:italic>\n                      = 0.51) LOS and additional cardioplegia volume (MD \u2212195.18\u00a0mL; [\u2212434.19 to 43.82];\n                      <jats:italic>p<\/jats:italic>\n                      = 0.11). The DN group had shorter hospital LOS (MD \u22120.81\u00a0days; [\u22121.25 to \u22120.36];\n                      <jats:italic>p<\/jats:italic>\n                      = 0.0003) and time under mechanical ventilation (MD \u22124.57\u00a0hours; [\u22128.73 to \u22120.42];\n                      <jats:italic>p<\/jats:italic>\n                      = 0.03). There was no difference in mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>DN cardioplegia has similar clinical outcomes and operative times compared to conventional blood cardioplegia in ToF surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02676591241312380","type":"journal-article","created":{"date-parts":[[2025,1,5]],"date-time":"2025-01-05T23:25:49Z","timestamp":1736119549000},"page":"1535-1545","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Del Nido versus conventional blood cardioplegia in tetralogy of fallot repair: A systematic review and meta-analysis of randomized controlled trials"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6954-6114","authenticated-orcid":false,"given":"Leo Noanh","family":"Consoli","sequence":"first","affiliation":[{"name":"Federal University of Bahia, Faculty of Medicine, Bahia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8191-4282","authenticated-orcid":false,"given":"Ilias Georgios","family":"Koziakas","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Onassis Cardiac Surgery Center, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meletios","family":"Kanakis","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Congenital Heart Surgery, Onassis Cardiac Surgery Center, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,1,5]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/bdr2.2301"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.5772\/53420"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(97)70231-9"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1051\/ject\/201244098"},{"issue":"1","key":"e_1_3_4_6_2","first-page":"24","article-title":"Effect of single-dose crystalloid cardioplegic agent compared to bloody cardioplegic agent in cardiac surgery in children with tetralogy of fallot","volume":"16","author":"Bigdelian H","year":"2020","unstructured":"Bigdelian H, Hosseini A. Effect of single-dose crystalloid cardioplegic agent compared to bloody cardioplegic agent in cardiac surgery in children with tetralogy of fallot. ARYA Atheroscler 2020; 16(1): 24\u201332.","journal-title":"ARYA Atheroscler"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/0267659119828890"},{"key":"e_1_3_4_8_2","unstructured":"Higgins JPT Thomas J Chandler J et al. Cochrane Handbook for systematic reviews of interventions version 6.3. 11-13 Cavendish Square London W1G 0AN United Kingdom: The Cochrane Collaboration 2023. https:\/\/www.training.cochrane.org\/handbook (Accessed 11 June 2024)."},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-4-200908180-00135"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/9781119536604.ch8"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_3_4_12_2","unstructured":"Sch\u00fcnemann H Bro\u017eek J Guyatt G et al. (eds) GRADE handbook for grading quality of evidence and strength of recommendations. McMaster University GRADE Center Canada: The GRADE Working Group 2013. https:\/\/www.guidelinedevelopment.org\/handbook (Accessed October 2013)."},{"key":"e_1_3_4_13_2","volume-title":"GRADEpro GDT: GRADEpro guideline development tool [software]","year":"2024","unstructured":"GRADEpro GDT: GRADEpro guideline development tool [software]. McMaster University GRADE Center, Canada: McMaster University and Evidence Prime, 2024. https:\/\/www.gradepro.org\/terms\/cite."},{"key":"e_1_3_4_14_2","volume-title":"Review manager (RevMan) [computer program]. Version 5.3","year":"2014","unstructured":"Review manager (RevMan) [computer program]. Version 5.3. 11-13 Cavendish Square London W1G 0AN United Kingdom: The Cochrane Collaboration, 2014. https:\/\/community.cochrane.org\/style-manual\/references\/reference-types\/software."},{"issue":"3","key":"e_1_3_4_15_2","first-page":"610","article-title":"Comparative study between the use of multidose standard cardioplegia and long-acting del Nido cardioplegia during intracardiac repair for tetralogy of fallot in pediatric patients","volume":"27","author":"Rushel KZ","year":"2018","unstructured":"Rushel KZ, Hoque A, Alamgir MK, et al. Comparative study between the use of multidose standard cardioplegia and long-acting del Nido cardioplegia during intracardiac repair for tetralogy of fallot in pediatric patients. Mymensingh Med J 2018; 27(3): 610\u2013616.","journal-title":"Mymensingh Med J"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semtcvs.2017.08.017"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/0267659117691119"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-195709000-00012"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1883.sp000120"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10194485"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)41007-6"},{"key":"e_1_3_4_22_2","first-page":"22","article-title":"Del Nido cardioplegia: from an infant conceive to an adult life - a brief review of the current evidence in adult patients","volume":"3","author":"Pragliola C","year":"2019","unstructured":"Pragliola C, Hassan E, Hossan AA, et al. 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