{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T22:43:16Z","timestamp":1789512196751,"version":"build-2803163510"},"reference-count":35,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T00:00:00Z","timestamp":1740873600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"NIH","award":["1K23HL157610"],"award-info":[{"award-number":["1K23HL157610"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perfusion"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Sparse data exist on delirium in VA-ECMO. We aim to describe the characteristics, risk factors, and outcomes of delirium in VA-ECMO.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed adults\u2019s electronic medical records on VA-ECMO in our ECMO registry in 2016\u20132022. Delirium was assessed by the Confusion Assessment Method for the intensive care unit when patients scored \u22123 or above on the Richmond Agitation-Sedation Scale. The primary outcomes were delirium prevalence and the proportion of delirium-present days while on VA-ECMO support. Multivariable logistic regression was used to evaluate delirium risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 208 patients (median [interquartile range] age: 53 [40\u201362]), 138 (66.3%) had delirium during ECMO. Delirium occurred on day 2.5 [1.0\u20137.0] of ECMO and was detected in 42% [20%\u201366%] of ECMO days. There were no differences in acute brain injury (24% vs 33%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = .34) between patients with and without delirium. Survival analysis showed no significant association between delirium and 30-day mortality (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = .24). In multivariable analysis, ECMO day 1 arterial carbon dioxide partial pressure (adjusted odds ratio [aOR] = 1.29; 95% CI = 1.03\u20131.73), number of sedatives (aOR = 2.67; 95% CI = 1.68\u20132.95), and African American race\/ethnicity (aOR = 16.45; 95% CI = 9.65\u201322.51) were associated with delirium.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Delirium was present in 66.3% of VA-ECMO patients and was detected early during ECMO. Modifiable risk factors included multiple sedative agents and early hypercapnia. Delirium did not increase risk for mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02676591251319684","type":"journal-article","created":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T13:34:29Z","timestamp":1741095269000},"page":"1762-1771","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Characteristics and risk factors of delirium in patients on veno-arterial extracorporeal membrane oxygenation"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4600-7243","authenticated-orcid":false,"given":"Olivia","family":"Liu","sequence":"first","affiliation":[{"name":"Johns Hopkins University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip Y.","family":"Sun","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed A.","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Kalra","sequence":"additional","affiliation":[{"name":"Thomas Jefferson University"},{"name":"Johns Hopkins Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Feng","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn J. 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