{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T09:26:58Z","timestamp":1787304418910,"version":"build-2736575974"},"reference-count":22,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perfusion"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>In patients with prior valve replacement requiring venoarterial extracorporeal membrane oxygenation (VA ECMO), there is a risk of prosthetic valve thrombosis (PVT) due to intracardiac stasis. We describe our experience with PVT in patients on VA ECMO.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective cohort study of patients with prior valve replacement undergoing VA ECMO. Patients who developed PVT on VA ECMO were compared to those who did not.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty-six patients who had prior valve replacement (total of 63 valves) were placed on VA ECMO. Six patients (13%) suffered PVT on VA ECMO. There was no difference in the rate of PVT in mitral versus aortic valve prostheses (22% [5\/23] vs 3% [1\/32];\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = .07) or between tissue and mechanical valves (16% [8\/50] vs 0% [0\/13];\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = .19). There were no differences in ECMO parameters, including site of cannulation (central vs peripheral), initial ECMO flow, time to initiation of anticoagulation, or use of a concomitant IABP between patients who did and did not develop PVT. Patients who developed PVT demonstrated significantly lower pulse pressures compared to those who did not (12.7\u00a0mmHg vs 32.7\u00a0mmHg;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = .03). Surgical thrombectomy was performed in three of the six patients with PVT and one survived to discharge.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PVT occurred in 13% of patients on VA ECMO after prior valve replacement. The only predictor of PVT on VA ECMO was a lower pulse pressure. Strategies to maintain intracardiac flow and pulsatility may reduce this risk. Treatment options are limited and pose significant risk, and therefore prevention is key.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02676591251393361","type":"journal-article","created":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T16:50:12Z","timestamp":1762015812000},"page":"909-916","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Prosthetic valve thrombosis on venoarterial extracorporeal membrane oxygenation support: Risk factors and outcomes"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0135-580X","authenticated-orcid":false,"given":"Berhane","family":"Worku","sequence":"first","affiliation":[{"name":"New York Presbyterian Weill Cornell Medical Center"},{"name":"New York Presbyterian Brooklyn Methodist Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Rossi","sequence":"additional","affiliation":[{"name":"New York Presbyterian Weill Cornell Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabeel","family":"Sami","sequence":"additional","affiliation":[{"name":"New York Presbyterian Brooklyn Methodist Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivancarmine","family":"Gambardella","sequence":"additional","affiliation":[{"name":"New York Presbyterian Weill Cornell Medical Center"},{"name":"New York Presbyterian Brooklyn Methodist Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandhya","family":"Balaram","sequence":"additional","affiliation":[{"name":"New York Presbyterian Weill Cornell Medical Center"},{"name":"New York Presbyterian Brooklyn Methodist Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iosif","family":"Gulkarov","sequence":"additional","affiliation":[{"name":"New York Presbyterian Weill Cornell Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Mack","sequence":"additional","affiliation":[{"name":"New York Presbyterian Weill Cornell Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8630-1100","authenticated-orcid":false,"given":"Mohit","family":"Aspal","sequence":"additional","affiliation":[{"name":"New York Presbyterian Weill Cornell Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Tukacs","sequence":"additional","affiliation":[{"name":"New York Presbyterian Weill Cornell Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshifumi","family":"Naka","sequence":"additional","affiliation":[{"name":"New York Presbyterian Weill Cornell Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0882-4691","authenticated-orcid":false,"given":"Ankur","family":"Srivastava","sequence":"additional","affiliation":[{"name":"New York Presbyterian Weill Cornell Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,11,1]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/02676591231152723"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezae321"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivaa125"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/02676591221114954"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redar.2018.12.010"},{"issue":"5","key":"e_1_3_5_7_2","first-page":"282","article-title":"Thrombosed stuck mitral valve during advanced mechanical circulatory support for post-cardiotomy shock","volume":"25","author":"Takami Y","year":"2022","unstructured":"Takami Y, Hoshino N, Ishikawa H, et al. Thrombosed stuck mitral valve during advanced mechanical circulatory support for post-cardiotomy shock. J Cardiol Cases 2022; 25(5): 282\u2013284.","journal-title":"J Cardiol Cases"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.005583"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.16122"},{"issue":"4","key":"e_1_3_5_10_2","first-page":"263","article-title":"Acute bioprosthetic mitral valve thrombosis during venoarterial extracorporeal membrane","volume":"26","author":"Monzon\u00eds AM","year":"2019","unstructured":"Monzon\u00eds AM, Munin MR, Del RSV, et al. Acute bioprosthetic mitral valve thrombosis during venoarterial extracorporeal membrane. Rev Port Cir Cardiotorac Vasc 2019; 26(4): 263\u2013265.","journal-title":"Rev Port Cir Cardiotorac Vasc"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivv150"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2018.05.007"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2012.02.021"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40981-017-0086-5"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xjtc.2020.04.020"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjcr\/ytaa085"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/02676591231157200"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40981-022-00586-5"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2012.11.061"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12921"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2023.08.023"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.15845"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/aor.13662"}],"container-title":["Perfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02676591251393361","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/02676591251393361","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02676591251393361","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T08:57:07Z","timestamp":1787302627000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/02676591251393361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,1]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1177\/02676591251393361"],"URL":"https:\/\/doi.org\/10.1177\/02676591251393361","relation":{},"ISSN":["0267-6591","1477-111X"],"issn-type":[{"value":"0267-6591","type":"print"},{"value":"1477-111X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,1]]}}}